Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier
文献类型：期刊论文
| 作者 | Guo,Zhaopei ; Tian,Huayu ; Lin,Lin ; Chen,Jie ; He,Chaoliang ; Tang,Zhaohui ; Chen,Xuesi |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:10页码:1406-1414 |
| 关键词 | GENE DELIVERY VECTORS GLYCOL) COPOLYMERS BUFFERING CAPACITY CANCER-THERAPY DNA DELIVERY PEI POLY(GLYCOAMIDOAMINE)S NANOPARTICLES TRANSFECTION PBLG |
| 通讯作者 | tian,hy |
| 英文摘要 | successful gene therapy for cancer treatment and various human genetic diseases relies on high efficient gene carriers, and many carriers can efficiently deliver plasmid dna to cells, while most of them are unefficient in sirna delivery. in this study, a series of amphiphilic copolymers are synthesized for pdna and sirna delivery by grafting hydrophobic polyalanine to polyethylenimine (named ppas). there are 12.5, 7.2, 12.3 and 11.3 times of gene expression more than pei in hela, 293t, a549 and cho cell lines for the optimal ppas, and the highest luciferase knockdown efficiency in huh7 and ct26 cells are investigated to be 90.4% and 89.0%, respectively. this meant the ppas have the potential as efficient transfection reagents for pdna and sirna delivery in future gene therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57243]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guo,Zhaopei,Tian,Huayu,Lin,Lin,et al. Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier[J]. macromolecular bioscience,2014,14(10):1406-1414. |
| APA | Guo,Zhaopei.,Tian,Huayu.,Lin,Lin.,Chen,Jie.,He,Chaoliang.,...&Chen,Xuesi.(2014).Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier.macromolecular bioscience,14(10),1406-1414. |
| MLA | Guo,Zhaopei,et al."Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier".macromolecular bioscience 14.10(2014):1406-1414. |
入库方式： OAI收割
来源：长春应用化学研究所
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