Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry
文献类型：期刊论文
| 作者 | Hu, Yu ; Jin, Jing ; Han, Yuanyuan ; Yin,Jinghua ; Jiang,W ; Liang,Haojun |
| 刊名 | rsc advances
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:15页码:7716-7724 |
| 关键词 | SELF-ASSEMBLED MONOLAYERS X-RAY REFLECTIVITY PROTEIN ADSORPTION QCM-D TITANIUM-OXIDE POLYMER-FILMS CHAIN DENSITY THIN-FILMS REAL-TIME GOLD |
| 通讯作者 | jiang,w |
| 英文摘要 | protein adsorption behavior is a key factor that determines whether materials can be used as medical polymer materials. in this study, fibrinogen (fib) adsorptions on three different poly(ethylene glycol) (peg) surfaces that differed in chain length and chain density were investigated using a quartz crystal microbalance with dissipation (qcm-d) and a dual polarization interferometry (dpi) with respect to adsorbed masses, viscoelastic properties and chain conformations. on qcm-d chips, peg chains were tight and in extended brush conformations. meanwhile, on dpi chips, peg(1000) and peg(2000) may have the same pancake-like conformations, but peg(5000) had a mushroom conformation. moreover, several bare spaces were observed on the loose pancake-like peg(1000)- and peg(2000)-modified dpi surfaces. fib could fully spread on the relatively dense peg(1000)-modified dpi surface and partly spread and tightly orient on the relatively sparse peg(2000)-modified dpi surface. thus, grafting density was found to have greater significance in determining fib adsorption resistance due to its influence on fib spreading when the chain conformations of hydrophilic molecules were loose pancake-like structures. furthermore, brush and mushroom structured peg(5000) chains both had high deformation capacity, which excellently resisted protein adsorption by adjusting their conformation to decrease interaction with fib. therefore, the fib adsorption resistance of peg-modified surface depended on the grafting density of peg layer and the deformation capacity of the peg chain. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330241000052 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57251]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hu, Yu,Jin, Jing,Han, Yuanyuan,et al. Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry[J]. rsc advances,2014,4(15):7716-7724. |
| APA | Hu, Yu,Jin, Jing,Han, Yuanyuan,Yin,Jinghua,Jiang,W,&Liang,Haojun.(2014).Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry.rsc advances,4(15),7716-7724. |
| MLA | Hu, Yu,et al."Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry".rsc advances 4.15(2014):7716-7724. |
入库方式： OAI收割
来源：长春应用化学研究所
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