Cyclic RGD targeting nanoparticles with pH sensitive polymer-drug conjugates for effective treatment of melanoma
文献类型：期刊论文
| 作者 | Guan, Xingang ; Hu, Xiuli ; Liu, Shi ; Huang,Yubin ; Jing,Xiabin ; Xie,Zhigang |
| 刊名 | rsc advances
 |
| 出版日期 | 2014 |
| 卷号 | 4期号:98页码:55187-88194 |
| 关键词 | ANTITUMOR EFFICACY DELIVERY SYSTEM CANCER-THERAPY TUMOR VASCULATURE ANTICANCER DRUGS MICELLES MICROENVIRONMENT BIODISTRIBUTION THERAPEUTICS PRODRUG |
| 通讯作者 | xie,zg |
| 英文摘要 | it is highly desirable to design and develop multifunctional nanoparticles for improving specificity, tumor accumulation and therapeutic efficacy. a strategy of combining active targeting with tumor microenvironmental response in one polymeric drug delivery system was developed via assembling a c(rgdfk)-linked copolymer and a ph sensitive polymer-epirubicin conjugate in aqueous solution. these hybrid micelles with a diameter of less than 100 nm showed ph sensitive drug release behaviours in vitro, which could be used for assisting tumor targeting and drug delivery. confocal laser scanning microscopy and flow cytometry results indicated that they can enhance the endocytosis by b16f10 cells. moreover, the hybrid micelles displayed a synergistic effect and led to increased cytotoxicity in vitro and enhanced antitumor efficacy in vivo. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57281]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guan, Xingang,Hu, Xiuli,Liu, Shi,et al. Cyclic RGD targeting nanoparticles with pH sensitive polymer-drug conjugates for effective treatment of melanoma[J]. rsc advances,2014,4(98):55187-88194. |
| APA | Guan, Xingang,Hu, Xiuli,Liu, Shi,Huang,Yubin,Jing,Xiabin,&Xie,Zhigang.(2014).Cyclic RGD targeting nanoparticles with pH sensitive polymer-drug conjugates for effective treatment of melanoma.rsc advances,4(98),55187-88194. |
| MLA | Guan, Xingang,et al."Cyclic RGD targeting nanoparticles with pH sensitive polymer-drug conjugates for effective treatment of melanoma".rsc advances 4.98(2014):55187-88194. |
入库方式： OAI收割
来源：长春应用化学研究所
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