A co-delivery system based on paclitaxel grafted mPEG-b-PLG loaded with doxorubicin: Preparation, in vitro and in vivo evaluation
文献类型：期刊论文
| 作者 | Li, Qian ; Lv, Shixian ; Tang, Zhaohui ; Liu,Muhua ; Zhang,Dawei ; Yang,Yan ; Chen,Xuesi |
| 刊名 | international journal of pharmaceutics
 |
| 出版日期 | 2014 |
| 卷号 | 471期号:1-2页码:412-420 |
| 关键词 | CELL LUNG-CANCER ANTICANCER DRUG-DELIVERY POLYMERIC MICELLES PROSTATE-CANCER BREAST-CANCER THERAPY COMBINATION POLYPEPTIDE CISPLATIN NANOPARTICLES |
| 通讯作者 | tang,zh |
| 英文摘要 | herein, we develop a co-delivery system of paclitaxel (ptx) and doxorubicin hydrochloride (dox center dot hcl) based on methoxypoly(ethylene glycol)-block-poly(l-glutamic acid) (mpeg-b-plg) for cancer treatment. ptx was grafted to the mpeg-b-plg by esterification to give mpeg-b-plg-g-ptx. dox center dot hcl was encapsulated via electrostatic interaction and hydrophobic stack between the dox center dot hcl and mpeg-bplg-g-ptx in aqueous solution. the release rate of dox center dot hcl from the drug-loaded nanoparticles (mpeg-b-plg-g-ptx-dox) was slow at blood ph (ph 7.4), but obviously increased at endosome ph (ph 5.4). the mpeg-b-plg-g-ptx-dox exhibited slight synergistic effect in inhibition of proliferation of a549 and mcf-7 human cancer cells. for in vivo treatment of xenograft human breast tumor (mcf-7), the mpeg-bplg-g-ptx-dox nanoparticles exhibited remarkable tumor inhibition effect with a 95.5% tumor-suppression-rate which was significantly higher than those of related single anticancer agents such as free dox center dot hcl and mpeg-b-plg-g-ptx. these results indicated that the mpeg-b-plg-g-ptx-dox would have great potential in cancer therapy. (c) 2014 elsevier b.v. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57304]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, Qian,Lv, Shixian,Tang, Zhaohui,et al. A co-delivery system based on paclitaxel grafted mPEG-b-PLG loaded with doxorubicin: Preparation, in vitro and in vivo evaluation[J]. international journal of pharmaceutics,2014,471(1-2):412-420. |
| APA | Li, Qian.,Lv, Shixian.,Tang, Zhaohui.,Liu,Muhua.,Zhang,Dawei.,...&Chen,Xuesi.(2014).A co-delivery system based on paclitaxel grafted mPEG-b-PLG loaded with doxorubicin: Preparation, in vitro and in vivo evaluation.international journal of pharmaceutics,471(1-2),412-420. |
| MLA | Li, Qian,et al."A co-delivery system based on paclitaxel grafted mPEG-b-PLG loaded with doxorubicin: Preparation, in vitro and in vivo evaluation".international journal of pharmaceutics 471.1-2(2014):412-420. |
入库方式： OAI收割
来源：长春应用化学研究所
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