A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
文献类型：期刊论文
| 作者 | Qi, Yao ; Pi, Zifeng ; Liu, Shu ; Song,Fengrui ; Lin,Na ; Liu,Zhiqiang |
| 刊名 | molecular biosystems
 |
| 出版日期 | 2014 |
| 卷号 | 10期号:10页码:2617-2625 |
| 关键词 | RHEUMATOID-ARTHRITIS IMMUNE ACTIVATION METABOLOMIC ANALYSIS URINE METHOTREXATE TRYPTOPHAN SERUM MS |
| 通讯作者 | pi,zf |
| 英文摘要 | rheumatoid arthritis (ra) is a chronic systemic inflammatory and autoimmune disease accompanied by the destruction and deformities of joints. adjuvant-induced arthritis (aia) is one of the excellent animal models of ra used to understand disease pathogenesis and screen potential drugs. in this paper, a urinary metabonomics method based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (uplc-q-tof-ms) has been established to investigate the disease progression of aia and find potential biomarkers of secondary inflammation in aia rats. 24 potential biomarkers were identified, including xanthurenic acid, kynurenic acid, 4-pyridoxic acid, and phenylalanine, which revealed that tryptophan metabolism, phenylalanine metabolism, gut microbiota metabolism and energy metabolism were disturbed in aia rats. these potential biomarkers and their corresponding pathways are helpful to further understand the mechanisms of aia and pathogenesis of ra. this study demonstrates that metabonomics based on uplc-q-tof-ms is a powerful methodology to analyze the underlying disease pathogenesis. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57361]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Qi, Yao,Pi, Zifeng,Liu, Shu,et al. A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry[J]. molecular biosystems,2014,10(10):2617-2625. |
| APA | Qi, Yao,Pi, Zifeng,Liu, Shu,Song,Fengrui,Lin,Na,&Liu,Zhiqiang.(2014).A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.molecular biosystems,10(10),2617-2625. |
| MLA | Qi, Yao,et al."A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry".molecular biosystems 10.10(2014):2617-2625. |
入库方式： OAI收割
来源：长春应用化学研究所
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