Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized Polypeptides
文献类型：期刊论文
| 作者 | Xiao, Chunsheng ; Cheng, Yilong ; Zhang, Yu ; Ding,Jianxun ; He,Chaoliang ; Zhuang,Xiuli ; Chen,Xuesi |
| 刊名 | journal of polymer science part a-polymer chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 52期号:5页码:671-679 |
| 关键词 | RING-OPENING POLYMERIZATION DRUG-DELIVERY THERMORESPONSIVE BEHAVIORS POLY(L-GLUTAMIC ACID) BIOMEDICAL APPLICATIONS N-CARBOXYANHYDRIDE PHASE-TRANSITION FACILE SYNTHESIS POLYMERS COPOLYMERS |
| 通讯作者 | chen,xs |
| 英文摘要 | the systemic investigation of the structural impacts of side chains on the ph- and thermo-responsiveness of tertiary amine functionalized poly(l-glutamate)s (ta-pgs) was carried out. the ta-pgs polymers were effectively synthesized by cu(i)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(-propargyl-l-glutamate) (pplg). turbimetric measurements were performed to characterize the ph- and temperature-induced phase transition of ta-pgs in aqueous solution, which suggested a structural dependence of the properties on the n-substituted groups and the linkers between 1,2,3-triazole ring and the tertiary amine groups in the side chains. in detail, the ph responsive properties of ta-pgs were basically determined by the hydrophobicity of the n-substituted groups in the side chains and the ph transition point (ph(t)) decreased as the increasing hydrophobicity of the n-substituted groups, while the temperature-responsiveness of ta-pgs were affected by either the n-substituted groups or the linkers. ta-pgs with a moderate n-substituted amine group (e.g., dea, pr, and pd) or a branched linker (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the lcst-type phase transition tuned by ph variation. these structure-property relationships revealed in this study would help to develop the applications of ta-pgs in smart drug delivery systems. (c) 2013 wiley periodicals, inc. j. polym. sci., part a: polym. chem. 2014, 52, 671-679 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57365]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiao, Chunsheng,Cheng, Yilong,Zhang, Yu,et al. Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized Polypeptides[J]. journal of polymer science part a-polymer chemistry,2014,52(5):671-679. |
| APA | Xiao, Chunsheng.,Cheng, Yilong.,Zhang, Yu.,Ding,Jianxun.,He,Chaoliang.,...&Chen,Xuesi.(2014).Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized Polypeptides.journal of polymer science part a-polymer chemistry,52(5),671-679. |
| MLA | Xiao, Chunsheng,et al."Side Chain Impacts on pH- and Thermo- Responsiveness of Tertiary Amine Functionalized Polypeptides".journal of polymer science part a-polymer chemistry 52.5(2014):671-679. |
入库方式： OAI收割
来源：长春应用化学研究所
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