Recent advances in ytterbium-based contrast agents for in vivo X-ray computed tomography imaging: promises and prospects
文献类型：期刊论文
| 作者 | Liu, Yanlan ; Liu, Jianhua ; Ai, Kelong ; Yuan,Qinghai ; Lu,Lehui |
| 刊名 | contrast media & molecular imaging
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:1页码:26-36 |
| 关键词 | BISMUTH SULFIDE NANOPARTICLES LARGE-SCALE SYNTHESIS GOLD NANOPARTICLES MAGNETIC-RESONANCE NONINVASIVE DETECTION OXIDE NANOPARTICLES CT MEDIA GADOLINIUM VITRO |
| 通讯作者 | lu,lh |
| 英文摘要 | x-ray computed tomography (ct) imaging is one of the most widely used diagnostic imaging techniques in the clinic, and has raised significant interest in recent years both in research and practice owing to its many advantages such as deep penetration depth, high resolution and facile image processing. developing heavy metal-based ct contrast agents, especially heavy metal-containing nanoparticulate ct contrast agents, has become a key focus in research fields to address issues of clinical iodinated agents involving short circulation time, low contrast efficiency and potential renal toxicity. in this review, we summarize the development of ytterbium (yb)-based ct contrast agents and highlight the design and applications of yb-based nanoparticulate ct contrast agents. yb has high atomic number and higher abundance in the earth's crust relative to au, ta and bi, which have received much attention as a ct contrast agents. in particular, in contrast to these metal elements, as well as i, yb has k-edge energy that is located just within the higher-intensity region of x-ray spectra, which can induce significant enhancement in the contrast efficiency. when encapsulated in nanoparticles, yb can remain in the circulation for a long time. this long in vivo circulation time, combined with the proper k-edge energy and a large absorption cross-section of yb in the near-infrared region, makes yb-based nanoparticles particularly promising in angiography, multicolor' spectral ct imaging, and multimodal imaging. finally, we also discuss the prospects and the challenges in the development of yb-based ct contrast agents. copyright (c) 2014 john wiley & sons, ltd. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57393]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu, Yanlan,Liu, Jianhua,Ai, Kelong,et al. Recent advances in ytterbium-based contrast agents for in vivo X-ray computed tomography imaging: promises and prospects[J]. contrast media & molecular imaging,2014,9(1):26-36. |
| APA | Liu, Yanlan,Liu, Jianhua,Ai, Kelong,Yuan,Qinghai,&Lu,Lehui.(2014).Recent advances in ytterbium-based contrast agents for in vivo X-ray computed tomography imaging: promises and prospects.contrast media & molecular imaging,9(1),26-36. |
| MLA | Liu, Yanlan,et al."Recent advances in ytterbium-based contrast agents for in vivo X-ray computed tomography imaging: promises and prospects".contrast media & molecular imaging 9.1(2014):26-36. |
入库方式： OAI收割
来源：长春应用化学研究所
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