Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine
文献类型：期刊论文
| 作者 | Chen, Jie ; Xia, Jialiang ; Tian, Huayu ; Tang,Zhaohui ; He,Chaoliang ; Chen,Xuesi |
| 刊名 | archives of pharmacal research
 |
| 出版日期 | 2014 |
| 卷号 | 37期号:1页码:142-148 |
| 关键词 | DRUG-DELIVERY POLY(AMIDOAMINE) DENDRIMERS BIOMEDICAL APPLICATIONS SENSITIVE HYDROGEL PH POLYMERS TEMPERATURE NANOPARTICLES GENE COPOLYMER |
| 通讯作者 | tian,hy |
| 英文摘要 | novel thermo- and ph-dual responsive amphiphilic copolymers were synthesized based on hyperbranched polyethylenimine (pei) by grafting l-phenylalanine. the phenylalanine-modified pei exhibited lower cytotoxicity than commercial pei. these copolymers showed the phenomena of phase transitions in response to ph and temperature. the dilute copolymer solution at lower ph displayed the higher lcst. furthermore, lcst increased with the increasing of phenylalanine grafting density. lcst of these copolymers were tunable from 7.2 to 59.6 a degrees c by the degree of amidation and ph of solution. dls and tem experiments certified that the copolymer chains aggregated to form small size particles as increasing the temperature above lcst. for these reasons, the obtained smart copolymers were considered to be potential gene/drug carriers in biomedical field. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57444]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen, Jie,Xia, Jialiang,Tian, Huayu,et al. Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine[J]. archives of pharmacal research,2014,37(1):142-148. |
| APA | Chen, Jie,Xia, Jialiang,Tian, Huayu,Tang,Zhaohui,He,Chaoliang,&Chen,Xuesi.(2014).Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine.archives of pharmacal research,37(1),142-148. |
| MLA | Chen, Jie,et al."Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine".archives of pharmacal research 37.1(2014):142-148. |
入库方式： OAI收割
来源：长春应用化学研究所
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