Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent
文献类型：期刊论文
| 作者 | Xiao, Yan ; Xue, Rong ; You, Tianyan ; Li,Xiaojing ; Pei,Fengkui ; Wang,Xuxia ; Lei,Hao |
| 刊名 | carbohydrate research
 |
| 出版日期 | 2014 |
| 卷号 | 395期号:33页码:9-14 |
| 关键词 | GADOLINIUM CHELATE PROTON RELAXATION MRI COMPLEXES BINDING DESIGN MODEL |
| 通讯作者 | you,ty |
| 英文摘要 | a novel biocompatible macromolecule (ag-cm-eda-dota-gd) was synthesized as a liver magnetic resonance imaging (mri) contrast agent. ag-cm-eda-dota-gd consisted of a carboxymethyl-arabinogalactan unit conjugated with gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (gd-dota) via ethylenediamine, and was specifically designed to bind to hepatocyte asialoglycoprotein in vivo, in an effort to develop a potential new tool for the diagnosis of liver diseases. the t-1-relaxivity (8.87 mmol(-1) l s(-1)) of ag-cm-eda-dota-gd was 1.86 times than that of gd-dota (4.76 mmol(-1) l s(-1)) in d2o at 9.4 t and 25 degrees c. mri experiments showed significant enhancement in rat liver following the intravenous administration of ag-cm-eda-dota-gd (0.094 mmol gd3+/kg body weight), which persisted for longer than gd-dota (0.098 mmol gd3+/kg body weight). the mean percentage enhancements in the liver parenchyma were 85.2 +/- 6.5% and 19.3 +/- 3.3% for ag-cm-eda-dota-gd and gd-dota, respectively. the results of this study therefore indicate that ag-cm-eda-dota-gd could be used as a potential liver-targeting contrast agent for mm. (c) 2014 elsevier ltd. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57455]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiao, Yan,Xue, Rong,You, Tianyan,et al. Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent[J]. carbohydrate research,2014,395(33):9-14. |
| APA | Xiao, Yan.,Xue, Rong.,You, Tianyan.,Li,Xiaojing.,Pei,Fengkui.,...&Lei,Hao.(2014).Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent.carbohydrate research,395(33),9-14. |
| MLA | Xiao, Yan,et al."Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent".carbohydrate research 395.33(2014):9-14. |
入库方式： OAI收割
来源：长春应用化学研究所
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