Studies on the biological character of a new pH-sensitive doxorubicin prodrug with tumor targeting using a LC-MS/MS method
文献类型：期刊论文
| 作者 | Zhang, Ruixing ; Hu, Xiuli ; Song, Fengrui ; Liu,Zhiqiang ; Xie,Zhigang ; Jing,Xiabin |
| 刊名 | analytical methods
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:9页码:3159-3166 |
| 关键词 | MACROMOLECULAR DRUG CARRIER IN-VITRO BLOCK-COPOLYMER CANCER-CHEMOTHERAPY ANTITUMOR-ACTIVITY HPMA COPOLYMERS DELIVERY ANTICANCER MICELLES VIVO |
| 通讯作者 | song,fr |
| 英文摘要 | a ph-sensitive doxorubicin (dox) prodrug was prepared, and its release in vitro and distribution in vivo were studied by using a high performance liquid chromatography combined with tandem mass spectrometry (lc-ms/ms) method. the prodrug, mpeg-p(la-co-dhp/dox) (p(dox)), was amphiphilic in nature, with a hydrophilic mpeg block and a hydrophobic p(la-co-dhp/dox) block. the dox was connected to the carrier polymer chain via a hydrazine linkage. the in vitro release results showed that the release rate of dox from p(dox) in acidic medium (ph = 5.0) was dramatically higher than that under physiological conditions (ph = 7.4). the absorption of dox from p(dox) in hela cells was much faster than that of free dox. the mtt cell viability study demonstrated the higher cytotoxicity of p(dox) than free dox at the same concentration. the dox concentration from p(dox) in the mouse liver was dramatically higher than those in other tissues. the above results showed that p(dox), as a prodrug of dox, greatly favors the bioavailability of doxorubicin and prolongs its circle time in vivo. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334736500046 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57474]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang, Ruixing,Hu, Xiuli,Song, Fengrui,et al. Studies on the biological character of a new pH-sensitive doxorubicin prodrug with tumor targeting using a LC-MS/MS method[J]. analytical methods,2014,6(9):3159-3166. |
| APA | Zhang, Ruixing,Hu, Xiuli,Song, Fengrui,Liu,Zhiqiang,Xie,Zhigang,&Jing,Xiabin.(2014).Studies on the biological character of a new pH-sensitive doxorubicin prodrug with tumor targeting using a LC-MS/MS method.analytical methods,6(9),3159-3166. |
| MLA | Zhang, Ruixing,et al."Studies on the biological character of a new pH-sensitive doxorubicin prodrug with tumor targeting using a LC-MS/MS method".analytical methods 6.9(2014):3159-3166. |
入库方式： OAI收割
来源：长春应用化学研究所
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