Mapping the resting and stimulated EGFR in cell membranes with topography and recognition imaging
文献类型：期刊论文
| 作者 | Zhao, Weidong ; Pan, Yangang ; Wu, Jiazhen ; Cai,Mingjun ; Tian,Yongmei ; Xu,Haijiao ; Yu,Lihua ; Wang,Hongda |
| 刊名 | analytical methods
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:19页码:7689-7694 |
| 关键词 | ATOMIC-FORCE MICROSCOPY GROWTH-FACTOR RECEPTOR LIPID RAFTS CANCER ACTIVATION BIOLOGY BINDING OLIGOMERIZATION SEQUESTRATION SPECTROSCOPY |
| 通讯作者 | wang,hd |
| 英文摘要 | epidermal growth factor receptor (egfr) is widely spread in various types of cells and plays critical roles in cellular activities. here we studied the egfr distribution before and after activation by high-resolution mapping technique-topography and recognition imaging (trec). the unbinding force between egfr and its ligand, epidermal growth factor (egf), was also measured by single-molecule force spectroscopy. our results suggest that the majority of egfrs are in the cluster state both in the resting and stimulated cells. this study provides qualitative information of the location, cluster state and binding kinetics of egfrs in cell membranes at the molecular level. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57481]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao, Weidong,Pan, Yangang,Wu, Jiazhen,et al. Mapping the resting and stimulated EGFR in cell membranes with topography and recognition imaging[J]. analytical methods,2014,6(19):7689-7694. |
| APA | Zhao, Weidong.,Pan, Yangang.,Wu, Jiazhen.,Cai,Mingjun.,Tian,Yongmei.,...&Wang,Hongda.(2014).Mapping the resting and stimulated EGFR in cell membranes with topography and recognition imaging.analytical methods,6(19),7689-7694. |
| MLA | Zhao, Weidong,et al."Mapping the resting and stimulated EGFR in cell membranes with topography and recognition imaging".analytical methods 6.19(2014):7689-7694. |
入库方式： OAI收割
来源：长春应用化学研究所
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