Biodegradable Polymersomes from Four-Arm PEG-b-PDLLA for Encapsulating Hemoglobin
文献类型：期刊论文
| 作者 | Li, Wenliang ; Zhang, Wenjing ; Yang, Xiuyun ; Xie,Zhigang ; Jing,Xiabin |
| 刊名 | journal of applied polymer science
 |
| 出版日期 | 2014 |
| 卷号 | 131期号:12页码:40433 |
| 关键词 | BLOCK-COPOLYMERS JANUS DENDRIMERS MICELLES DELIVERY CARRIERS REDUCTION STABILITY VESICLES BEHAVIOR RELEASE |
| 通讯作者 | xie,zg |
| 英文摘要 | a series of four-arm star block copolymers poly(ethylene glycol)-block-poly(d,l-lactide) (peg-pdlla) with different hydrophobic length were synthesized by ring-opening polymerization of lactide and characterized using h-1 nmr and gel permeation chromatography (gpc). these copolymers could self-assemble in aqueous solution to form the vesicle structure with controlled size and morphologies. transmission electron microscopy (tem) and dls show the polymersomes are spherical with diameter of 70 approximate to 500 nm. the polymersomes made by direct hydration of copolymer thin films in water exhibit the controllable ability of encapsulating hemoglobin under mild condition. the hemoglobin content in the polymersomes could reach to 35 wt %. more importantly, the encapsulated hemoglobin keeps its own bioactivity and is capable of binding oxygen. this hemoglobin-encapsulated four-arm peg-pla polymersomes could have the potential to be applied as an artificial oxygen carrier for transfusion. (c) 2014 wiley periodicals, inc. j. appl. polym. sci. 2014, 131, 40433. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000333614300055 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57490]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, Wenliang,Zhang, Wenjing,Yang, Xiuyun,et al. Biodegradable Polymersomes from Four-Arm PEG-b-PDLLA for Encapsulating Hemoglobin[J]. journal of applied polymer science,2014,131(12):40433. |
| APA | Li, Wenliang,Zhang, Wenjing,Yang, Xiuyun,Xie,Zhigang,&Jing,Xiabin.(2014).Biodegradable Polymersomes from Four-Arm PEG-b-PDLLA for Encapsulating Hemoglobin.journal of applied polymer science,131(12),40433. |
| MLA | Li, Wenliang,et al."Biodegradable Polymersomes from Four-Arm PEG-b-PDLLA for Encapsulating Hemoglobin".journal of applied polymer science 131.12(2014):40433. |
入库方式： OAI收割
来源：长春应用化学研究所
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