Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity
文献类型：期刊论文
| 作者 | Hou, Guang-Yue ; Wang, Lu ; Liu, Shu ; Song,Feng-Rui ; Liu,Zhi-Qiang |
| 刊名 | 中国化学快报 chinese chemical letters
 |
| 出版日期 | 2014 |
| 卷号 | 25期号:7页码:1039-1043 |
| 关键词 | TRADITIONAL CHINESE MEDICINE DIABETIC COMPLICATIONS MASS-SPECTROMETRY ANTIOXIDANT MECHANISM RUTIN |
| 通讯作者 | song,fr |
| 英文摘要 | the formation of advanced glycation end-products (ages) and aldose reductase (ar) activity have been implicated in the development of diabetic complications. our study sought to characterize the capacities of eleven herbal extracts against the formation of ages and the ar activity. an ultrahigh performance liquid chromatography and tandem mass spectrometry (uplc-ms/ms) method was used for the detection of ar activity and the screening of ar inhibitors in this research. the amount of sorbitol from each analyte was directly detected using the multiple reaction monitoring mode and the sorbitol level could be reduced via the addition of an inhibitor. moreover, the bsa/glucose (fructose) system was applied to investigate their inhibitory activities of ages formation in glycation model reactions. compared with other screened herbs used in our study, flos sophorae immaturus and radix scutellariae seemed to be more effective on inhibiting the formation of ages and ar activity. the inhibiting capacities of herbal extracts against ar activity and ages formation may be correlated with the bioactive components of the herbal extracts. the differences were correlated with the amount of polyphenol and flavonoid components. in the study, we have investigated the potential anti-hyperglycemic bioactivity of eleven herbal extracts in vitro, which could provide a reference for further in vivo research in the prevention and treatment of diabetic complications. (c) 2014 feng-rui song. published by elsevier b.v. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340223400015 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57506]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hou, Guang-Yue,Wang, Lu,Liu, Shu,et al. Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity[J]. 中国化学快报 chinese chemical letters,2014,25(7):1039-1043. |
| APA | Hou, Guang-Yue,Wang, Lu,Liu, Shu,Song,Feng-Rui,&Liu,Zhi-Qiang.(2014).Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity.中国化学快报 chinese chemical letters,25(7),1039-1043. |
| MLA | Hou, Guang-Yue,et al."Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity".中国化学快报 chinese chemical letters 25.7(2014):1039-1043. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。