Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn
文献类型：期刊论文
| 作者 | Xu Chen ; Liu Shu ; Liu Zhiqiang ; Song,Rengrui |
| 刊名 | 高等学校化学学报 chemical journal of chinese universities-chinese
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:8页码:1640-1645 |
| 关键词 | ALPHA-GLUCOSIDASE INHIBITORS MASS-SPECTROMETRY FREE-RADICALS URIC-ACID EXTRACT DISEASE SERUM ANTIOXIDANTS IONIZATION ALKALOIDS |
| 通讯作者 | liu,s |
| 英文摘要 | an ultrafiltration uplc/q-tof/ms assay and in vitro xanthine oxidase inhibition assay were combined to screen xanthine oxidase inhibitors in traditional chinese herbal formulae ermiaowan. the result of in vitro xanthine oxidase inhibition assay showed that ermiaowan had a strong xanthine oxidase inhibitory activity, the ic50 value was (0.218 +/- 0.0034) mg/ml. nine compounds were screened and identified as potential xanthine oxidase inhibitors in ermiaowan using ultrafiltration uplc/q-tof/ms. this work provides a certain basis for the development of xanthine oxidase inhibitors and the mechanism clarification of ermiaowan to treat gout and hyperuricemia. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57544]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu Chen,Liu Shu,Liu Zhiqiang,et al. Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn[J]. 高等学校化学学报 chemical journal of chinese universities-chinese,2014,35(8):1640-1645. |
| APA | Xu Chen,Liu Shu,Liu Zhiqiang,&Song,Rengrui.(2014).Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn.高等学校化学学报 chemical journal of chinese universities-chinese,35(8),1640-1645. |
| MLA | Xu Chen,et al."Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MSn".高等学校化学学报 chemical journal of chinese universities-chinese 35.8(2014):1640-1645. |
入库方式： OAI收割
来源：长春应用化学研究所
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