Effect of Cancer Drug LHRH-PE40 on the Elasticity of Living HeLa Cells
文献类型：期刊论文
| 作者 | Zhang Jing ; Zhang Bai-Lin ; Tang Ji-Lin |
| 刊名 | 分析化学 chinese journal of analytical chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 42期号:6页码:811-816 |
| 关键词 | ATOMIC-FORCE MICROSCOPY SINGLE-MOLECULE SPECTROSCOPY |
| 通讯作者 | zhang,bl |
| 英文摘要 | the quantitative analysis of biomechanical profiles at the single-cell level can provide additional information. the careful analysis of biomechanical properties at the single-cell level can provide additional information that is usually not available using traditional biological methods, but may be crucial to assess and understand tumor progress and response to chemotherapy. in this study, the on-line changes of cell elasticity during the exposure to immunotoxin lhrh-pe40 were monitored by atomic force microscopy (afm) on living hela cell surface under physiological condition. the results from afm based force spectroscopy showed that lhrh-pe40 induced a distinct increase of the cell surface stiffness of hela cells. the fluorescence images implied that the cancer drug lhrh-pe40 would affect the re-organization of actin microfilaments, which led to the increase of the stiffness of hela cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340673200003 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57551]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang Jing,Zhang Bai-Lin,Tang Ji-Lin. Effect of Cancer Drug LHRH-PE40 on the Elasticity of Living HeLa Cells[J]. 分析化学 chinese journal of analytical chemistry,2014,42(6):811-816. |
| APA | Zhang Jing,Zhang Bai-Lin,&Tang Ji-Lin.(2014).Effect of Cancer Drug LHRH-PE40 on the Elasticity of Living HeLa Cells.分析化学 chinese journal of analytical chemistry,42(6),811-816. |
| MLA | Zhang Jing,et al."Effect of Cancer Drug LHRH-PE40 on the Elasticity of Living HeLa Cells".分析化学 chinese journal of analytical chemistry 42.6(2014):811-816. |
入库方式： OAI收割
来源：长春应用化学研究所
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