Effects of Ginseng Aqueous Extract on Neurochemicals in Diabetic Encephalopathy Rat Brain by Online Microdialysis-LC-MS/MS
文献类型：期刊论文
| 作者 | Wang Qian-Qian ; Zhang Jing ; Pi Zi-Feng |
| 刊名 | 分析化学 chinese journal of analytical chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 42期号:7页码:997-1001 |
| 关键词 | Ginseng aqueous extract Diabetic encephalopathy Morris water maze Online microdialysis-liquid chromatography-tandem mass spectrometry Neurochemicals |
| 通讯作者 | pi,zf |
| 英文摘要 | to evaluate the effects of ginseng aqueous extract on learning and memory abilities and neurochemicals in diabetic encephalopathy rat brain. diabetes mellitus model was established. cognitive abilities were evaluated with morris water maze test by the indexes of escape latency time (elt), times of passing through the target area and the percent of swimming track in goal quadrant. we applied online md-lc-ms/ms method to determine eight neurochemicals in rat hippocampus among different groups in mrm mode. venusil c18 column was used for separation. treatment with ginseng aqueous extract significantly improved the cognitive abilities of diabetic rats (p<0.05). the method had excellent linearity (r-2 > 0.99). the accuracy and precision could meet the analysis requirement. comparing with the model group, the concentrations of taurine and acetylcholine were significantly increased (p<0.01) after treated with ginseng aqueous extract, but the glutamic acid, aspartic acid, gamma-aminobutyric acid, serine, dopamine and serotonine decreased dramatically. ginseng aqueous extract can efficiently regulate the levels of eight neurochemials in diabetic rat brain to normal. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57552]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang Qian-Qian,Zhang Jing,Pi Zi-Feng. Effects of Ginseng Aqueous Extract on Neurochemicals in Diabetic Encephalopathy Rat Brain by Online Microdialysis-LC-MS/MS[J]. 分析化学 chinese journal of analytical chemistry,2014,42(7):997-1001. |
| APA | Wang Qian-Qian,Zhang Jing,&Pi Zi-Feng.(2014).Effects of Ginseng Aqueous Extract on Neurochemicals in Diabetic Encephalopathy Rat Brain by Online Microdialysis-LC-MS/MS.分析化学 chinese journal of analytical chemistry,42(7),997-1001. |
| MLA | Wang Qian-Qian,et al."Effects of Ginseng Aqueous Extract on Neurochemicals in Diabetic Encephalopathy Rat Brain by Online Microdialysis-LC-MS/MS".分析化学 chinese journal of analytical chemistry 42.7(2014):997-1001. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。