Preparation of Novel Biocompatible Macromolecular Magnetic Resonance Imaging Contrast Agent
文献类型：期刊论文
| 作者 | Xiao Yan ; Xue Rong ; Zhan You-Yang ; Qi,Chen-Li ; You,Tian-Yan ; Li,Xiao-Jing ; Pei,Feng-Kui |
| 刊名 | 分析化学 chinese journal of analytical chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 42期号:10页码:1421-1425 |
| 关键词 | Magnetic resonance imaging Poly-(amine acid) Biocompatibility Liver-specificity |
| 通讯作者 | li,xj |
| 英文摘要 | poly (aspartic acid-co-leucine) (pl) synthesized with aspartic acid and leucine was conjugated to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (dota) by ethylenediamine. then the compound obtained was chelated with gadolinium (iii) to form pl-a(2)-dota-gd. the structure of pl-a(2)-dota-gd was characterized by nuclear magnetic resonance and gel chromatography and its performance was evaluated by cytotoxicity test, heamolysis test, in vitro relaxivity determination and animal in vivo magnetic resonance characterization. pl-a(2)-dota-gd exhibited much lower cytotoxicity than gd-dota. the t1-relaxivity of pl-a(2)-dota-gd (15.3 mm(-1) s(-1)) was 2.6 times than that of gd-dota (5.8 mm(-1) s(-1)) in d2o. the results of magnetic resonance imaging (mri) experiments showed a significant enhancement in the rat liver imaging after the intravenous administration of pl-a(2)-dota-gd. in addition, the imaging time persisted by using pl-a(2)-dota-gd than that of gd-dota and the imaging effect of liver tissue was enhanced by an average of 65.1% +/- 5.2% and 21.3% +/- 4.9% for pl-a(2)-dota-gd and gd-dota, respectively. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57553]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xiao Yan,Xue Rong,Zhan You-Yang,et al. Preparation of Novel Biocompatible Macromolecular Magnetic Resonance Imaging Contrast Agent[J]. 分析化学 chinese journal of analytical chemistry,2014,42(10):1421-1425. |
| APA | Xiao Yan.,Xue Rong.,Zhan You-Yang.,Qi,Chen-Li.,You,Tian-Yan.,...&Pei,Feng-Kui.(2014).Preparation of Novel Biocompatible Macromolecular Magnetic Resonance Imaging Contrast Agent.分析化学 chinese journal of analytical chemistry,42(10),1421-1425. |
| MLA | Xiao Yan,et al."Preparation of Novel Biocompatible Macromolecular Magnetic Resonance Imaging Contrast Agent".分析化学 chinese journal of analytical chemistry 42.10(2014):1421-1425. |
入库方式： OAI收割
来源：长春应用化学研究所
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