EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS
文献类型：期刊论文
| 作者 | Pi, Zifeng ; Jiang, Hongyu ; Zhang, Jing ; Tao,Li ; Song,Fengrui ; Liu,Zhiqing |
| 刊名 | journal of liquid chromatography & related technologies
 |
| 出版日期 | 2014 |
| 卷号 | 37期号:17页码:2478-2489 |
| 关键词 | MELLITUS SPECTROMETRY METABONOMICS DIAGNOSIS SERUM NMR |
| 通讯作者 | jiang,hy |
| 英文摘要 | four kinds of endogenous metabolites, including creatinine, phenylacetylglycine, hippuric acid, and gluconic acid, were as potential biomarkers by a urinary metabolomics method in our previous study. to confirm them and investigate the effect of acarbose on type 2 diabetes in rats, a sensitive and selective ultra performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) method was developed to determine the concentration of the four kinds of endogenous metabolites in the urine of diabetes rats between pre- and post-treatment by acarbose. the results showed that the four kinds of endogenous metabolites were authenticated as the urinary biomarker of the diabetes rats. but after treating with acarbose, the content of phenylacetylglycine was significantly decreased in the urine of diabetic rats, while the content of other three kinds of endogenous metabolites did not change significantly. this means that phenylacetylglycine related intestinal bacteria metabolic pathway probably was the major pathway during the treatment of acarbose and the effect on other metabolic pathways related to creatinine, hippuric acid, and gluconic acid metabolites was relatively weak. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57567]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Pi, Zifeng,Jiang, Hongyu,Zhang, Jing,et al. EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS[J]. journal of liquid chromatography & related technologies,2014,37(17):2478-2489. |
| APA | Pi, Zifeng,Jiang, Hongyu,Zhang, Jing,Tao,Li,Song,Fengrui,&Liu,Zhiqing.(2014).EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS.journal of liquid chromatography & related technologies,37(17),2478-2489. |
| MLA | Pi, Zifeng,et al."EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS".journal of liquid chromatography & related technologies 37.17(2014):2478-2489. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。