Precise patterning of the SEBS surface by UV lithography to evaluate the platelet function through single platelet adhesion
文献类型：期刊论文
| 作者 | Ye, Wei ; Shi, Qiang ; Wong, Shing-Chung ; Hou,Jianwei ; Xu,Xiaodong ; Yin,Jinghua |
| 刊名 | biomaterials science
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:9页码:1186-1194 |
| 关键词 | BCL-X(L)-INHIBITORY BH3 MIMETICS WHOLE-BLOOD DIGITAL QUANTIFICATION FIBRINOGEN PLASMA FLOW IMMOBILIZATION AGGREGATION ACTIVATION DEATH |
| 通讯作者 | ye,w |
| 英文摘要 | platelets have exhibited capabilities beyond clotting in recent years. most of their functions are related to the nature of platelet adhesion. establishing a facile method to understand the platelet adhesion and assess the platelet function through the mechanism and mechanics of adhesion is highly desired. here, we report a generally applicable uv lithography technique with a photomask, which performs selective surface functionalization on large substrate areas, for creating stable, physical adhesive sites in the range of 12 m to 3 m. our study demonstrated that the patterned surface facilitated probing of single platelet adhesion in a quantitative manner, and rendered platelets sensitive to adhesive proteins even at a low protein concentration. in addition, the platelet function in the presence of antiplatelet (anticancer) agents on platelets could be accurately estimated based on single platelet adhesion (spa). this work paves a new way to understand and assess the blood platelet function. the spa assay methodology has the potential to enable a rapid, accurate point-of-care platform suitable for evaluation of platelet function, detection of dysfunctional platelets, and assay of drug effects on platelets in cancer patients. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57573]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ye, Wei,Shi, Qiang,Wong, Shing-Chung,et al. Precise patterning of the SEBS surface by UV lithography to evaluate the platelet function through single platelet adhesion[J]. biomaterials science,2014,2(9):1186-1194. |
| APA | Ye, Wei,Shi, Qiang,Wong, Shing-Chung,Hou,Jianwei,Xu,Xiaodong,&Yin,Jinghua.(2014).Precise patterning of the SEBS surface by UV lithography to evaluate the platelet function through single platelet adhesion.biomaterials science,2(9),1186-1194. |
| MLA | Ye, Wei,et al."Precise patterning of the SEBS surface by UV lithography to evaluate the platelet function through single platelet adhesion".biomaterials science 2.9(2014):1186-1194. |
入库方式： OAI收割
来源：长春应用化学研究所
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