Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode
文献类型：期刊论文
| 作者 | Yu, Li-Jia1,2; Gai, Wei1,2; Yang, Qian-Fan1; Xiang, Jun-Feng1; Sun, Hong-Xia1; Li, Qian1; Wang, Li-Xia1; Guan, Ai-Jiao1; Tang, Ya-Lin1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 26期号:6页码:705-708 |
| 关键词 | Parallel-stranded G-quadruplex Cyanine dye Dual-site binding mode c-myc |
| 英文摘要 | G-quadruplexes (G4s) play important roles in biological systems, such as telomere maintenance, replication, and transcription. Based on the DNA sequence, loop geometry, and the local environments, G4s can be classified into different conformations. It is important to detect different types of G4s to monitor the diseases related with G4s. Most ligands bind to G4s based on end-stacking modes, while rare ligands bind to G4s through groove binding modes. We have found that a cyanine dye DMSB interacts with parallel G4 by end-stacking and groove simultaneous binding mode. In this article, we found that DMSB could simply discriminate parallel G4s from other DNA motifs by using UV-vis spectrum. These results give some clues to develop high specificity G4 probes. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27912]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & State Specie, Beijing Natl Lab Mol Sci,Ctr Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Li-Jia,Gai, Wei,Yang, Qian-Fan,et al. Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode[J]. CHINESE CHEMICAL LETTERS,2015,26(6):705-708. |
| APA | Yu, Li-Jia.,Gai, Wei.,Yang, Qian-Fan.,Xiang, Jun-Feng.,Sun, Hong-Xia.,...&Tang, Ya-Lin.(2015).Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode.CHINESE CHEMICAL LETTERS,26(6),705-708. |
| MLA | Yu, Li-Jia,et al."Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode".CHINESE CHEMICAL LETTERS 26.6(2015):705-708. |
入库方式： OAI收割
来源：化学研究所
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