A comparative study for recognizing G-quadruplexes using dimeric cyanine dyes with different sizes of aromatic substituents
文献类型：期刊论文
| 作者 | Yu, Lijia1,2; Yang, Qianfan1; Xiang, Junfeng1; Tang, Yalin1 |
| 刊名 | ANALYTICAL METHODS
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:13页码:5483-5489 |
| 英文摘要 | A series of dimeric cyanine dyes with different sizes of heterocyclic aromatic substituents and the same linker were synthesized, and these dyes were demonstrated to be highly selective compounds for binding to G-quadruplex DNA. These results showed that the size of heterocyclic aromatic substituents had great influence on the self-assembly properties of these dyes as well as their interaction with G-quadruplex motifs. A dye with a large aromatic substituent (AB-P4) formed strong aggregates and also presented significant selectivity for the G-quadruplex over duplex DNA. In contrast, dyes with small aromatic rings (B-P4 and TC-P4) had a much smaller effect on the recognition of the G-quadruplex, suggesting that the possession of a suitably sized plane for good pi-pi stacking with the G-quadruplex was essential for the interaction of dyes with the G-quadruplex. Moreover, the loop structures of the G-quadruplex also affected the binding mode of AB-P4 with the G-quadruplex: loops located at the side of the tetrad were favorable for both end-stacking binding modes in the form of monomers, while more hindrance by the loop at one end of the tetrads resulted in one end-stacking on the G-quadruplex in the form of dimers. In comparison, loops play weak roles in dyes with TC-P4, and this dye could stack on both ends of tetrads. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27949]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci ICCAS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing Natl Lab Mol Sci, Ctr Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Lijia,Yang, Qianfan,Xiang, Junfeng,et al. A comparative study for recognizing G-quadruplexes using dimeric cyanine dyes with different sizes of aromatic substituents[J]. ANALYTICAL METHODS,2015,7(13):5483-5489. |
| APA | Yu, Lijia,Yang, Qianfan,Xiang, Junfeng,&Tang, Yalin.(2015).A comparative study for recognizing G-quadruplexes using dimeric cyanine dyes with different sizes of aromatic substituents.ANALYTICAL METHODS,7(13),5483-5489. |
| MLA | Yu, Lijia,et al."A comparative study for recognizing G-quadruplexes using dimeric cyanine dyes with different sizes of aromatic substituents".ANALYTICAL METHODS 7.13(2015):5483-5489. |
入库方式： OAI收割
来源：化学研究所
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