G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch
文献类型：期刊论文
| 作者 | Guan, Ai-Jiao1; Shen, Meng-Jie2; Xiang, Jun-Feng1; Zhang, En-Xuan1; Li, Qian1; Sun, Hong-Xia1; Wang, Li-Xia1; Xu, Guang-Zhi1; Tang, Ya-Lin1; Xu, Li-Jin2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-05-20 |
| 卷号 | 5 |
| 英文摘要 | Nucleic acid based molecular device is a developing research field which attracts great interests in material for building machinelike nanodevices. G-quadruplex, as a new type of DNA secondary structures, can be harnessed to construct molecular device owing to its rich structural polymorphism. Herein, we developed a switching system based on G-quadruplexes and methylazacalix[6]pyridine (MACP6). The induced circular dichroism (CD) signal of MACP6 was used to monitor the switch controlled by temperature or pH value. Furthermore, the CD titration, Job-plot, variable temperature CD and H-1-NMR experiments not only confirmed the binding mode between MACP6 and G-quadruplex, but also explained the difference switching effect of MACP6 and various G-quadruplexes. The established strategy has the potential to be used as the chiral probe for specific G-quadruplex recognition. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28114]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci, Ctr Mol Sci, Inst Chem,Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 3.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Ai-Jiao,Shen, Meng-Jie,Xiang, Jun-Feng,et al. G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Guan, Ai-Jiao.,Shen, Meng-Jie.,Xiang, Jun-Feng.,Zhang, En-Xuan.,Li, Qian.,...&Gong, Han-Yuan.(2015).G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch.SCIENTIFIC REPORTS,5. |
| MLA | Guan, Ai-Jiao,et al."G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：化学研究所
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