The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation
文献类型：期刊论文
| 作者 | Zou, Toujun1,2; Zhen, Mingming1; Chen, Daiqin1,2; Li, Ruimin1,2; Guan, Mirong1,2; Shu, Chunying1; Han, Hongbin3; Wang, Chunru1 |
| 刊名 | DALTON TRANSACTIONS
 |
| 出版日期 | 2015 |
| 卷号 | 44期号:19页码:9114-9119 |
| 英文摘要 | Manganese-porphyrin compounds as MRI contrast agents have drawn particular attention due to high relaxivities and unique biodistribution. It has been reported that the charge density of the metal center and steric decompression of the substituents, rather than rotational correlation time, were the key factors to determine the relaxivities of manganese(III) porphyrins. In this study, [6,6]-phenyl-C-61-butyric acid (PC(61)BA) was introduced into 5-(4-aminophenyl)-10,15,20-tris (4-sulfonatophenyl) porphyrin (APTSPP) to investigate the influence on water proton relaxation. The obtained PC(61)BA-APTSPP-Mn possesses a relaxivity of 19.2 mM(-1) s(-1), which is greater than that of Mn-APTSPP (11.2 mM(-1) s(-1)) and clinically used Gd-DTPA (4.1 mM(-1) s(-1)) at 0.5 T, and even more effective compared with those binding manganese(III) porphyrins to certain macromolecules. It was reasonably speculated that the high relaxivity of PC(61)BA-APTSPP-Mn should ascribe to the charge density variation of MnIII and steric decompression induced by PC(61)BA. Both fluorescence emission spectra and cyclic voltammetry results verified the presence of electronic communication between PC(61)BA and APTSPP-Mn. In addition, the hydrodynamic diameter of PC(61)BA-APTSPP-Mn aggregates was much smaller than that of APTSPP-Mn aggregates, which may contribute to the higher relaxivity by inhibiting the formation of dimers of APTSPP-Mn. Therefore, the introduction of fullerene derivatives is suggested to be a good strategy for the improvement of the relaxivities of manganese(III) porphyrins. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28031]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, Toujun,Zhen, Mingming,Chen, Daiqin,et al. The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation[J]. DALTON TRANSACTIONS,2015,44(19):9114-9119. |
| APA | Zou, Toujun.,Zhen, Mingming.,Chen, Daiqin.,Li, Ruimin.,Guan, Mirong.,...&Wang, Chunru.(2015).The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation.DALTON TRANSACTIONS,44(19),9114-9119. |
| MLA | Zou, Toujun,et al."The positive influence of fullerene derivatives bonded to manganese(III) porphyrins on water proton relaxation".DALTON TRANSACTIONS 44.19(2015):9114-9119. |
入库方式： OAI收割
来源：化学研究所
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