Palladium-catalyzed asymmetric allylic amination of racemic butadiene monoxide with isatin derivatives
文献类型：期刊论文
| 作者 | Li, Gen; Feng, Xiangqing; Du, Haifeng |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:20页码:5826-5830 |
| 英文摘要 | Isatins and their derivatives are important functional moities and building blocks in pharmaceutical and synthetic chemistry. Numerous enantioselective transformations at the C-3 carbonyl group have been well developed. However, the asymmetric substitution reaction with isatins and their derivatives as nucleophiles based on the free N-H groups has been less studied due to the relatively weaker nucleophilicity resulting from the two electron-withdrawing carbonyl groups. In this paper, a palladium-catalyzed asymmetric allylic amination of racemic butadiene monoxide with isatin derivatives using a chiral phosphoramidite olefin hybrid ligand has been successfully developed under mild conditions. A variety of chiral amino alcohols were afforded in 55-87% yields with 10/1->20/1 regioselectivity ratios and 80-97% ees. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28086]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Gen,Feng, Xiangqing,Du, Haifeng. Palladium-catalyzed asymmetric allylic amination of racemic butadiene monoxide with isatin derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(20):5826-5830. |
| APA | Li, Gen,Feng, Xiangqing,&Du, Haifeng.(2015).Palladium-catalyzed asymmetric allylic amination of racemic butadiene monoxide with isatin derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,13(20),5826-5830. |
| MLA | Li, Gen,et al."Palladium-catalyzed asymmetric allylic amination of racemic butadiene monoxide with isatin derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 13.20(2015):5826-5830. |
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来源：化学研究所
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