Acid-Labile Poly(glycidyl methacrylate)-Based Star Gene Vectors
文献类型：期刊论文
| 作者 | Yang, Yon-Yu1,2,3; Hu, Hao2,3; Wang, Xing1; Yang, Fei1; Shen, Hong1; Xu, Fu-Jian2,3; Wu, De-Cheng1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2015-06-10 |
| 卷号 | 7期号:22页码:12238-12248 |
| 关键词 | gene vector acetal linker star-shaped acid-lability biodegradation |
| 英文摘要 | It was recently reported that ethanolamine-functionalized poly(glycidyl methacrylate) (PGEA) possesses great potential applications in gene therapy due to its good biocompatibility and high transfection efficiency. Importing responsivity into PGEA vectors would further improve their performances. Herein, a series of responsive star-shaped vectors, acetaled beta-cyclodextrin-PGEAs (A-CD-PGEAs) consisting of a beta-CD core and five PGEA arms linked by acid-labile acetal groups, were proposed and characterized as therapeutic pDNA vectors. The A-CD-PGEAs owned abundant hydroxyl groups to shield extra positive charges of A-CD-PGEAs/pDNA complexes, and the star structure could decrease charge density. The incorporation of acetal linkers endowed A-CD-PGEAs with pH responsivity and degradation. In weakly acidic endosome, the broken acetal linkers resulted in decomposition of A-CD-PGEAs and morphological transformation of A-CD-PGEAs/pDNA complexes, lowering cytotoxicity and accelerating release of pDNA. In comparison with control CD-PGEAs without acetal linkers, A-CD-PGEAs exhibited significantly better transfection performances. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27955]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing 100029, Peoples R China 3.Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yon-Yu,Hu, Hao,Wang, Xing,et al. Acid-Labile Poly(glycidyl methacrylate)-Based Star Gene Vectors[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(22):12238-12248. |
| APA | Yang, Yon-Yu.,Hu, Hao.,Wang, Xing.,Yang, Fei.,Shen, Hong.,...&Wu, De-Cheng.(2015).Acid-Labile Poly(glycidyl methacrylate)-Based Star Gene Vectors.ACS APPLIED MATERIALS & INTERFACES,7(22),12238-12248. |
| MLA | Yang, Yon-Yu,et al."Acid-Labile Poly(glycidyl methacrylate)-Based Star Gene Vectors".ACS APPLIED MATERIALS & INTERFACES 7.22(2015):12238-12248. |
入库方式： OAI收割
来源：化学研究所
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