Injectable supramolecular hydrogels via inclusion complexation of mPEG-grafted copolyglutamate with alpha-cyclodextrin
文献类型：期刊论文
| 作者 | Wu, Lian-ying; Yu, Lei; Fu, Xiao-hui; Li, Zhi-bo |
| 刊名 | CHINESE JOURNAL OF POLYMER SCIENCE
 |
| 出版日期 | 2015-08-01 |
| 卷号 | 33期号:8页码:1140-1149 |
| 关键词 | Supramolecular hydrogel Inclusion complexation Copolyglutamate alpha-Cyclodextrin |
| 英文摘要 | A series of monomethoxy poly(ethylene glycol) (mPEG) grafted copolyglutamates (PmPEGs) were synthesized through ring-opening polymerization (ROP) followed by click chemistry. Supramolecular hydrogels based on polymer inclusion complexes (ICs) between PmPEG and alpha-cyclodextrin (alpha-CD) were prepared in aqueous solution. The rheological measurements indicated their gelation properties were affected by several factors including the mPEG length, graft density and the sample concentration. These hydrogels displayed thermo-sensitive gel-sol transition under appropriate conditions due to the reversible mPEG and alpha-CD inclusion complexation. These hydrogels also showed pH-sensitive behavior due to the deprotonate of carboxylic acid side groups. The ICs formation of a channel-type crystalline structure induced gelation mechanism was verified by various techniques. In vitro cytotoxicity assays demonstrated that the supramolecular hydrogels are nontoxic and cytocompatible. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27980]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Lian-ying,Yu, Lei,Fu, Xiao-hui,et al. Injectable supramolecular hydrogels via inclusion complexation of mPEG-grafted copolyglutamate with alpha-cyclodextrin[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2015,33(8):1140-1149. |
| APA | Wu, Lian-ying,Yu, Lei,Fu, Xiao-hui,&Li, Zhi-bo.(2015).Injectable supramolecular hydrogels via inclusion complexation of mPEG-grafted copolyglutamate with alpha-cyclodextrin.CHINESE JOURNAL OF POLYMER SCIENCE,33(8),1140-1149. |
| MLA | Wu, Lian-ying,et al."Injectable supramolecular hydrogels via inclusion complexation of mPEG-grafted copolyglutamate with alpha-cyclodextrin".CHINESE JOURNAL OF POLYMER SCIENCE 33.8(2015):1140-1149. |
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来源：化学研究所
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