Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery
文献类型：期刊论文
| 作者 | Kuang, Huihui1,2; Wu, Yanjuan1,2; Zhang, Zhiyun1,2; Li, Jizhen3; Chen, Xuesi4; Xie, Zhigang1; Jing, Xiabin1; Huang, Yubin1 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:19页码:3625-3633 |
| 英文摘要 | A double pH-responsive supramolecular copolymer micelle was successfully developed, which was based on complementary multiple hydrogen bonds of nucleobases and acetalated dextran. The thymine-terminated poly(ethylene glycol) (T-PEG-T) and adenine-terminated acetalated dextran (AcDEX-A) were synthesized and used to construct supramolecular amphiphilic triblock copolymer AcDEX-A: T-PEG-T: A-AcDEX, which could be further self-assembled into supramolecular micelles in water. These micelles were stable at pH 7.4, but disruptive at pH 5.0 due to the double pH-sensitivity of hydrogen bonds within the copolymer backbones and the hydrolysis of the acetalated dextran. The hydroxyl coverage of Ac-DEX had an important effect on the critical micelle concentration (CMC) and particle size of AcDEX-A: T-PEG-T: A-AcDEX micelles, which were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). In addition, turbidometry was utilized to evaluate the effect of pH-responsivity of AcDEX-A: T-PEG-T: A-AcDEX micelles and these supramolecular micelles were completely decomposed at pH 5.0. Cytotoxicity evaluation showed good biocompatibility of these micelles, and doxorubicin (DOX) was encapsulated into supramolecular micelles as a model drug. The in vitro drug release profile showed that the DOX release speed at pH 5.0 could be adjusted by changing the hydroxyl coverage of Ac-DEX. Meanwhile, DOX-loaded supramolecular micelles could be efficiently internalized into cancer cells and showed similar inhibition of proliferation of the Hela cell as free DOX. This work provided a new method for enabling a rapid intracellular release of drugs by using double pH-sensitive hydrogen bonds and acetalated dextran, which would have the potential to be applied in controlled drug delivery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28038]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Jilin Univ, Coll Chem, Dept Organ Chem, Changchun 130023, Peoples R China 4.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang, Huihui,Wu, Yanjuan,Zhang, Zhiyun,et al. Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery[J]. POLYMER CHEMISTRY,2015,6(19):3625-3633. |
| APA | Kuang, Huihui.,Wu, Yanjuan.,Zhang, Zhiyun.,Li, Jizhen.,Chen, Xuesi.,...&Huang, Yubin.(2015).Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery.POLYMER CHEMISTRY,6(19),3625-3633. |
| MLA | Kuang, Huihui,et al."Double pH-responsive supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases and acetalated dextran for drug delivery".POLYMER CHEMISTRY 6.19(2015):3625-3633. |
入库方式： OAI收割
来源：化学研究所
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