Combinatorial targeting polymeric micelles for anti-tumor drug delivery
文献类型：期刊论文
| 作者 | Yang, Saina1; Zhu, Feiyan2; Wang, Qian1; Liang, Fuxin1; Qu, Xiaozhong2; Gan, Zhihua3; Yang, Zhenzhong1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:19页码:4043-4051 |
| 英文摘要 | Polymeric micelles of amphiphilic block copolymers have been studied for decades for their application as a targeting delivery agent of anti-tumor drugs. However, the targeting micelles may cause an immunological response because of the surface distributed ligands. In this work, mixed micelles were developed to improve the specificity of cancer cell uptake under tumor-acidic conditions. This was achieved by the co-assembly of an active targeting amphiphilic polymer, i.e. cyclic (Arg-Gly-Asp-D-Phe-Lys) c(RGDfK) functionalized poly(ethylene oxide)-b-poly(epsilon-caprolactone) (cRGD-PEO-b-PCL), and a pH sensitive drug conjugate, i.e. benzoic-imine linked PEGylated doxorubicin (PEG-DOX). Because the PEG-DOX is cleavable at the extracellular pH of a solid tumor, the characteristics of the mixed micelles turn from "stealthy" to cancer cell-affinitive due to the detachment of PEG from the micelle surface and hence allow the action of the c(RGDfK) in the cRGD-PEO-b-PCL with the cancer cell membrane. Besides, the mixed micelles exhibited the capacity for encapsulating hydrophobic drugs such as paclitaxel to form a combination formulation. Our results indicate that co-assembly is a facile but efficient strategy to coordinate the characteristics of each individual component and thus provide combinatorial functions to the delivery system. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28044]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 3.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Saina,Zhu, Feiyan,Wang, Qian,et al. Combinatorial targeting polymeric micelles for anti-tumor drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(19):4043-4051. |
| APA | Yang, Saina.,Zhu, Feiyan.,Wang, Qian.,Liang, Fuxin.,Qu, Xiaozhong.,...&Yang, Zhenzhong.(2015).Combinatorial targeting polymeric micelles for anti-tumor drug delivery.JOURNAL OF MATERIALS CHEMISTRY B,3(19),4043-4051. |
| MLA | Yang, Saina,et al."Combinatorial targeting polymeric micelles for anti-tumor drug delivery".JOURNAL OF MATERIALS CHEMISTRY B 3.19(2015):4043-4051. |
入库方式： OAI收割
来源：化学研究所
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