A biomimetic 3D microtubule-orientated poly(lactide-co-glycolide) scaffold with interconnected pores for tissue engineering
文献类型：期刊论文
| 作者 | Shen, Hong1; Niu, Yuguang2; Hu, Xixue3; Yang, Fei1; Wang, Shenguo1; Wu, Decheng1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:21页码:4417-4425 |
| 英文摘要 | An ideal tissue engineering scaffold should imitate physical and biochemical cues of natural extracellular matrix and have interconnected porous structures with high porosity to provide adequate space for cell seeding, growth and proliferation, as well as nutrient delivery and metabolized product elimination. In this study, we examined the feasibility of fabricating microtubule-orientated poly(lactide-co-glycolide) (PLGA) scaffolds with interconnected pores (denoted as MOIP-PLGA) by an improved thermal-induced phase separation technique. We successfully constructed MOIP-PLGA using 1,4-dioxane as the first solvent and benzene or water with lower freezing point as the second solvent. Especially, when water was used, the MOIP-PLGA had higher porosity and it could guide rabbit aortic smooth muscle cells (SMCs) to better grow along the microtubule direction of the scaffold. Comparing with microtubule-orientated scaffold without interconnected pores (denoted as MONIP-PLGA), the proliferation and viability of SMCs cultured on MOIP-PLGA were higher. Moreover, basic fibroblast growth factor could be effectively bound on MOIP-PLGA by a plasma treatment technique and the growth factor could be slowly released in vitro, maintaining bioactivity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28090]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Acad Mil Med Sci, Affiliated Hosp, ENT Dept, Beijing 100071, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Hong,Niu, Yuguang,Hu, Xixue,et al. A biomimetic 3D microtubule-orientated poly(lactide-co-glycolide) scaffold with interconnected pores for tissue engineering[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(21):4417-4425. |
| APA | Shen, Hong,Niu, Yuguang,Hu, Xixue,Yang, Fei,Wang, Shenguo,&Wu, Decheng.(2015).A biomimetic 3D microtubule-orientated poly(lactide-co-glycolide) scaffold with interconnected pores for tissue engineering.JOURNAL OF MATERIALS CHEMISTRY B,3(21),4417-4425. |
| MLA | Shen, Hong,et al."A biomimetic 3D microtubule-orientated poly(lactide-co-glycolide) scaffold with interconnected pores for tissue engineering".JOURNAL OF MATERIALS CHEMISTRY B 3.21(2015):4417-4425. |
入库方式： OAI收割
来源：化学研究所
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