Axial Growth and Fusion of Liposome Regulated by Macromolecular Crowding and Confinement
文献类型：期刊论文
| 作者 | Liu, Yun1,2; Zhu, Lin1,2; Yang, Jingfa3; Sun, Jianbo1,2; Zhao, Jiang3; Liang, Dehai1,2 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2015-05-05 |
| 卷号 | 31期号:17页码:4822-4826 |
| 英文摘要 | The endomembrane system, including the endoplasmic reticulum, Golgi apparatus, lysosomes, and endosomes, is located in the crowded intracellular environment. An understanding of the cellular structure and functions requires knowledge of how macromolecular crowding and confinement affect the activity of membrane and its proteins. Using negatively charged liposome and the peptide K3L8K3 as a model system, we studied the aggregation behavior of liposome in a matrix of polyacrylamide and hyaluronic acid. Without matrix, the liposomes form spherical aggregates in the presence of K3L8K3. However, they orient in one dimension and fuse into a tube up to 40 mu m long in the matrix. The growth of the tube is via end-to-end connection. This anisotropic growth is mainly due to the macromolecular confinement provided by the polymer network. The study of the interactions between liposome and peptide in the crowded environment helps to reveal the mechanism of membrane-related processes in vivo. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28093]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Minist Educ, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Minist Educ, Key Lab Polymer Chem & Phys, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yun,Zhu, Lin,Yang, Jingfa,et al. Axial Growth and Fusion of Liposome Regulated by Macromolecular Crowding and Confinement[J]. LANGMUIR,2015,31(17):4822-4826. |
| APA | Liu, Yun,Zhu, Lin,Yang, Jingfa,Sun, Jianbo,Zhao, Jiang,&Liang, Dehai.(2015).Axial Growth and Fusion of Liposome Regulated by Macromolecular Crowding and Confinement.LANGMUIR,31(17),4822-4826. |
| MLA | Liu, Yun,et al."Axial Growth and Fusion of Liposome Regulated by Macromolecular Crowding and Confinement".LANGMUIR 31.17(2015):4822-4826. |
入库方式： OAI收割
来源：化学研究所
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