Tunable supramolecular hydrogels from polypeptide-PEG-polypeptide triblock copolymers
文献类型：期刊论文
| 作者 | Fu, Xiaohui1; Shen, Yong1; Ma, Yinan1; Fu, Wenxin1; Li, Zhibo1,2 |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 58期号:6页码:1005-1012 |
| 关键词 | hydrogel polypeptide N-carboxyanhydride (NCA) ring-opening polymerization (ROP) drug delivery |
| 英文摘要 | A series of ABA triblock copolymers of poly(gamma-(2-methoxy ethoxy)esteryl-glutamate)-block-poly(ethylene glycol)-block-poly(gamma-(2-methoxy ethoxy)esteryl-glutamate) with poly(ethylene glycol) as middle hydrophilic B block and oligo(ethylene glycol)-functionalized polyglutamate (poly-L-EG(2)Glu) as terminal A blocks were prepared via ring-opening polymerization of EG(2)Glu N-carboxyanhydride (NCA). The resulting P(EG(2)Glu)-b-PEG-b-P(EG(2)Glu) triblocks can spontaneously form hydrogels in water. The intermolecular hydrogen bonding interactions between polypeptides blocks were responsible for the formation of gel network structure. These hydrogels displayed shear-thinning and rapid recovery properties, which endowed them potential application as injectable drug delivery system. The mechanical strength of hydrogels can be modulated by copolymer composition, molecular weight and concentrations. Also, it was found that the hydrogels' strength decreased with temperature due to dehydration of polypeptide segments. Atomic force microscopy and scanning electron microscopy images revealed that these hydrogels were formed through micelle packing mechanism. Circular dichroism and Fourier transform infrared spectroscopy characterizations suggested the poly-L-EG(2)Glu block adopted mixed conformation. A preliminary assessment of drug release in vitro demonstrated the hydrogels can offer a sustained release of doxorubicin (DOX) and the release rate could be controlled by varying chemical composition. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28120]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Xiaohui,Shen, Yong,Ma, Yinan,et al. Tunable supramolecular hydrogels from polypeptide-PEG-polypeptide triblock copolymers[J]. SCIENCE CHINA-CHEMISTRY,2015,58(6):1005-1012. |
| APA | Fu, Xiaohui,Shen, Yong,Ma, Yinan,Fu, Wenxin,&Li, Zhibo.(2015).Tunable supramolecular hydrogels from polypeptide-PEG-polypeptide triblock copolymers.SCIENCE CHINA-CHEMISTRY,58(6),1005-1012. |
| MLA | Fu, Xiaohui,et al."Tunable supramolecular hydrogels from polypeptide-PEG-polypeptide triblock copolymers".SCIENCE CHINA-CHEMISTRY 58.6(2015):1005-1012. |
入库方式： OAI收割
来源：化学研究所
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