pH-Responsive polymeric Janus containers for controlled drug delivery
文献类型：期刊论文
| 作者 | Zhao, Ziguang1,2; Zhu, Feiyan2,3; Qu, Xiaozhong2,3; Wu, Qiuhua1; Wang, Qian2; Zhang, Guolin1; Liang, Fuxin2 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:22页码:4144-4153 |
| 英文摘要 | In this study, we develop a novel approach to fabricate pH-responsive polymeric Janus hollow spheres (JHSs) with bi-layered structures by two-step polymerization with silica particles as templates. The inner layer is the biodegradable poly(e-caprolactone) (PCL) brush and the outer layer is cross-linked pH-responsive poly(diethylaminoethylmethacrylate) (PDEAEMA). So, these as-synthesized JHSs can selectively load oil-soluble materials into the cavities and controllably release them by changing the pH. Doxorubicin (DOX) is selected as a model drug which is loaded into the cavity of the JHSs and showed faster release at acidic pH than at physiological pH. It was revealed that the intracellular uptake of JHSs at the pH of tumorous tissues was significantly larger than that under the same conditions at the pH of the normal physiological environment. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28166]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Liaoning Univ, Coll Chem, Liaoning Prov Key Lab Green Synth & Preparat Chem, Shenyang 110036, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ziguang,Zhu, Feiyan,Qu, Xiaozhong,et al. pH-Responsive polymeric Janus containers for controlled drug delivery[J]. POLYMER CHEMISTRY,2015,6(22):4144-4153. |
| APA | Zhao, Ziguang.,Zhu, Feiyan.,Qu, Xiaozhong.,Wu, Qiuhua.,Wang, Qian.,...&Liang, Fuxin.(2015).pH-Responsive polymeric Janus containers for controlled drug delivery.POLYMER CHEMISTRY,6(22),4144-4153. |
| MLA | Zhao, Ziguang,et al."pH-Responsive polymeric Janus containers for controlled drug delivery".POLYMER CHEMISTRY 6.22(2015):4144-4153. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。