Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A
文献类型：期刊论文
| 作者 | Wen, Hao1,2; Pan, Wei1,2; Zhou, Jihan1,2; Li, Zhibo3; Liang, Dehai1,2 |
| 刊名 | SOFT MATTER
 |
| 出版日期 | 2015-03-14 |
| 卷号 | 11期号:10页码:1930-1936 |
| 英文摘要 | Kanamycin A, an amino modified sugar, can interact with poly(ethylene glycol)-block-poly(glutamate sodium) (PEG(114)-PGlu(64)) via electrostatic interactions (with PGlu) and hydrogen bonding (with PEG). The interplay of these two forces determines the assembly process and the resulting structure. In deionized water, kanamycin A and PEG(114)-PGlu(64) form a spherical structure at [+]/[-] = 3.5. This structure dissociates instantly and completely in the presence of 30 mM NaCl. However, a new structure is reassembled in about 2 hours. A similar phenomenon is observed when the buffer pH is increased from 7.8 to 8.3. We attribute the distinct dissociation/reassembly process to the reestablishment of the balance between electrostatic interactions and hydrogen bonding. The dissociation/reassembly process in response to environmental changes offers a novel approach to release the loaded cargo in a controlled manner. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28201]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Minist Educ, Beijing 100871, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Key Lab Polymer Chem & Phys, Minist Educ, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Hao,Pan, Wei,Zhou, Jihan,et al. Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A[J]. SOFT MATTER,2015,11(10):1930-1936. |
| APA | Wen, Hao,Pan, Wei,Zhou, Jihan,Li, Zhibo,&Liang, Dehai.(2015).Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A.SOFT MATTER,11(10),1930-1936. |
| MLA | Wen, Hao,et al."Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A".SOFT MATTER 11.10(2015):1930-1936. |
入库方式： OAI收割
来源：化学研究所
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