Synthesis and Cellular Internalization of Spindle Hematite/Polymer Hybrid Nanoparticles
文献类型：期刊论文
| 作者 | Wang, Jing1; Zhu, Wen1; Liu, Lixin2; Chen, Yongming1,2; Wang, Chun3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2015-03-11 |
| 卷号 | 7期号:9页码:5454-5461 |
| 关键词 | cellular internalization grafted polymers HeLa cells hematite nanoparticles nonspherical particles |
| 英文摘要 | Nonspherical spindle-shaped hematite/polymer hybrid nanoparticles (SPNPs) were synthesized via surface-initiated atom transfer radical polymerization (SI-ATRP). The long axis of the SPNPs was 370 +/- 65 nm, and the short axis was 80 +/- 15 nm with an aspect ratio of 4.6-4.7. The SPNPs were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). Thermogravimetric analysis (TGA) was used to estimate the content of grafted polymer. Light-scattering measurement was used to detect the particle size distribution of SPNPs in water and in cell culture medium. HeLa cells internalized the SPNPs within 1 h, and the uptake reached equilibrium in 8 h. These observations contribute to better understanding of the interactions between nonspherical nanoparticles and cells, which may have implication for designing drug delivery vehicles. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28275]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Sun Yat Sen Univ, Sch Chem & Chem Engn, Dept Polymer & Mat Sci, Key Lab,Minist Educ Polymer Composite & Funct Mat, Guangzhou 510275, Guangdong, Peoples R China 3.Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Zhu, Wen,Liu, Lixin,et al. Synthesis and Cellular Internalization of Spindle Hematite/Polymer Hybrid Nanoparticles[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(9):5454-5461. |
| APA | Wang, Jing,Zhu, Wen,Liu, Lixin,Chen, Yongming,&Wang, Chun.(2015).Synthesis and Cellular Internalization of Spindle Hematite/Polymer Hybrid Nanoparticles.ACS APPLIED MATERIALS & INTERFACES,7(9),5454-5461. |
| MLA | Wang, Jing,et al."Synthesis and Cellular Internalization of Spindle Hematite/Polymer Hybrid Nanoparticles".ACS APPLIED MATERIALS & INTERFACES 7.9(2015):5454-5461. |
入库方式： OAI收割
来源：化学研究所
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