Whack-A- Mole Model: Towards a Unified Description of Biological Effects Caused by Radiation Exposure
文献类型：期刊论文
| 作者 | Manabe, Yuichiro1; Wada, Takahiro2; Tsunoyama, Yuichi3; Nakajima, Hiroo4; Nakamura, Issei5; Bando, Masako6,7 |
| 刊名 | JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN
 |
| 出版日期 | 2015-04-15 |
| 卷号 | 84期号:4 |
| 英文摘要 | We present a novel model to for estimating biological effects caused by artificial radiation exposure, i.e., the Whack-A-Mole (WAM) model. It is important to take into account the recovery effects during the time course of cellular reactions. The inclusion of dose-rate dependence is essential in the risk estimation of low-dose radiation, while nearly all the existing theoretical models rely on the total dose dependence only. By analyzing experimental data of the relationship between the radiation dose and the induced mutation frequency of five organisms, namely, mouse, Drosophila, chrysanthemum, maize, Tradescantia, we found that all the data can be reproduced by the WAM model. Most remarkably, a scaling function, which is derived from the WAM model, consistently accounts for the observed mutation frequencies of the five organisms. This is the first rationale to account for the dose rate dependence as well as to provide a unified understanding of a general feature of organisms. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28282]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Osaka Univ, Grad Sch Engn, Div Sustainable Energy & Environm Engn, Suita, Osaka 5650871, Japan 2.Kansai Univ, Fac Engn Sci, Dept Pure & Appl Phys, Suita, Osaka 5648680, Japan 3.Kyoto Univ, Div Biol, Radioisotope Res Ctr, Kyoto 6068502, Japan 4.Osaka Univ, Grad Sch Med, Dept Radiat Biol & Med Genet, Suita, Osaka 5650871, Japan 5.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 6.Kyoto Univ, Yukawa Inst Theoret Phys, Kyoto 6068502, Japan 7.Osaka Univ, Nucl Phys Res Ctr, Ibaraki, Osaka 5670047, Japan |
| 推荐引用方式 GB/T 7714 | Manabe, Yuichiro,Wada, Takahiro,Tsunoyama, Yuichi,et al. Whack-A- Mole Model: Towards a Unified Description of Biological Effects Caused by Radiation Exposure[J]. JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN,2015,84(4). |
| APA | Manabe, Yuichiro,Wada, Takahiro,Tsunoyama, Yuichi,Nakajima, Hiroo,Nakamura, Issei,&Bando, Masako.(2015).Whack-A- Mole Model: Towards a Unified Description of Biological Effects Caused by Radiation Exposure.JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN,84(4). |
| MLA | Manabe, Yuichiro,et al."Whack-A- Mole Model: Towards a Unified Description of Biological Effects Caused by Radiation Exposure".JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN 84.4(2015). |
入库方式： OAI收割
来源：化学研究所
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