cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery
文献类型：期刊论文
| 作者 | Guan, Xingang1,2; Hu, Xiuli1; Li, Zhihong3; Zhang, Hong3; Xie, Zhigang1 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:29页码:22957-22964 |
| 英文摘要 | Efficiently and selectively delivering chemotherapeutic agents to tumours still remains a challenge for the development of nanocarriers. In this study, polymer micelles based on cRGD targeting and pH-sensitive surface charge-switching were successfully prepared and used for doxorubicin (Dox) delivery. This nanoscale polymeric micelle indicated a high drug encapsulation efficiency of 90% and slightly negative charge. Drug release experiments showed a pH-enhanced release profile in PBS, which resulted from surface charge-switching by imidazole. Confocal laser scanning microscopy and flow cytometry experiments indicated that combining the capability of an RGD target and pH-sensitive charge-switching significantly enhanced the cellular uptake of B16F10 cells overexpressing alpha(v)beta(3) integrins. An MTT assay also showed that our hybrid RGD-decorated micelles were much more cytotoxic to B16F10 cells than undecorated micelles. These results suggest the potential application of a cRGD target and pH-sensitive surface charge-switching polymeric micelles in the treatment of alpha(v)beta(3) integrin-overexpressing cancers. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28283]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Beihua Univ, Life Sci Res Ctr, Jilin 132013, Peoples R China 3.Jilin Univ, Hosp 1, Dept Thorac Surg, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Xingang,Hu, Xiuli,Li, Zhihong,et al. cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery[J]. RSC ADVANCES,2015,5(29):22957-22964. |
| APA | Guan, Xingang,Hu, Xiuli,Li, Zhihong,Zhang, Hong,&Xie, Zhigang.(2015).cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery.RSC ADVANCES,5(29),22957-22964. |
| MLA | Guan, Xingang,et al."cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery".RSC ADVANCES 5.29(2015):22957-22964. |
入库方式： OAI收割
来源：化学研究所
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