Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery
文献类型：期刊论文
| 作者 | Lin, Wenhai1,2; Guan, Xingang1,3; Sun, Tingting1,2; Huang, Yubin1; Jing, Xiabing1; Xie, Zhigang1 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2015-02-01 |
| 卷号 | 126页码:217-223 |
| 关键词 | Multi-component Passerini reaction Reduction-sensitive Micelles Curcumin Drug delivery |
| 英文摘要 | One-step synthesis of amphiphilic polymers containing disulfide bond within the hydrophobic backbone was demonstrated via multi-component Passerini reaction. The obtained polymer was self-assembled into micelles in aqueous solution. Curcumin (CUR), an effective and safe anticancer agent, which was limited by its water insolubility and poor bioavailability, was loaded into the micelles as a model drug. The nanoscale polymeric micelles were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Faster intracellular CUR release was observed by confocal laser scanning microscopy (CLSM) in the HeLa cells pretreated with GSH than in the unpretreated ones. Micelles also loaded with NH2-BODIPY which was almost non-fluorescent and gave strong enhanced fluorescence under acid conditions. The phenomenon of the stronger enhanced fluorescence in the pretreated HeLa cells showed further that the obtained polymer was reduction-sensitive. In vitro MTT assays showed that the micelles were biocompatible and CUR-loaded micelles had higher cellular proliferation inhibition in contrast to free CUR toward HeLa cells. These results highlight the potential of using multi-component Passerini reaction to make functional copolymers as smart nanocarriers for drug delivery. (C) 2014 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28287]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10039, Peoples R China 3.Beihua Univ, Life Sci Res Ctr, Fengman 132013, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Wenhai,Guan, Xingang,Sun, Tingting,et al. Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2015,126:217-223. |
| APA | Lin, Wenhai,Guan, Xingang,Sun, Tingting,Huang, Yubin,Jing, Xiabing,&Xie, Zhigang.(2015).Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery.COLLOIDS AND SURFACES B-BIOINTERFACES,126,217-223. |
| MLA | Lin, Wenhai,et al."Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery".COLLOIDS AND SURFACES B-BIOINTERFACES 126(2015):217-223. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。