Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex
文献类型：期刊论文
| 作者 | Yu, Chunshui1; Lin, Fuchun2; Zhao, Li3; Ye, Jing3; Qin, Wen1 |
| 刊名 | INTELLIGENCE
 |
| 出版日期 | 2009-03-01 |
| 卷号 | 37期号:2页码:174-180 |
| 关键词 | Tuberous sclerosis complex Intelligence Diffusion tensor Magnetic resonance imaging Brain White matter |
| 英文摘要 | Whether patients with tuberous sclerosis complex (TSC) have brain normal-appearing white matter (NAWM) damage and whether such damage contributes to their intellectual disability were examined in 15 TSC patients and 15 gender- and age-matched healthy controls using diffusion tensor imaging (DTI). Histogram and region of interest (ROI) analyses of the mean diffusivity (MD) and fractional anisotropy (FA) were performed in the NAWM. Correlations between diffusion indices and the full-scale intelligence quotient (FSIQ) and normalized lesion volume were also investigated. Compared with controls, both histogram and ROI analyses showed significant (P<.05) increased MD and decreased FA in the NAWM of TSC patients. In TSC patients, some of the histogram- and ROI-derived diffusion indices of the NAWM were correlated with FSIQ (P<.01), but none of them were correlated with the normalized lesion volume. These findings indicate that TSC patients have occult damage in the NAWM, which might be an important neural basis for intellectual disability in these patients. (C) 2008 Elsevier Inc. All rights reserved. |
| WOS标题词 | Social Sciences |
| 类目[WOS] | Psychology, Multidisciplinary |
| 研究领域[WOS] | Psychology |
| 关键词[WOS] | DIFFUSION TENSOR IMAGES ; MENTAL-RETARDATION ; INFANTILE SPASMS ; MULTIPLE-SCLEROSIS ; MRI FINDINGS ; BRAIN ; INTELLIGENCE ; CHILDREN ; EPILEPSY ; TRACT |
| 收录类别 | SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264911900007 |
| 公开日期 | 2015-11-02 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8164]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Capital Med Univ, Dept Radiol, Xuanwu Hosp, Beijing 100053, Peoples R China 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Peoples R China 3.Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Chunshui,Lin, Fuchun,Zhao, Li,et al. Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex[J]. INTELLIGENCE,2009,37(2):174-180. |
| APA | Yu, Chunshui,Lin, Fuchun,Zhao, Li,Ye, Jing,&Qin, Wen.(2009).Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex.INTELLIGENCE,37(2),174-180. |
| MLA | Yu, Chunshui,et al."Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex".INTELLIGENCE 37.2(2009):174-180. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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