Probing the dynamics of growth factor receptor by single-molecule fluorescence imaging
文献类型：期刊论文
| 作者 | Sun, Yahong; Li, Nan; Fang, Xiaohong |
| 刊名 | PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 118期号:3页码:95-102 |
| 关键词 | Single-molecule fluorescence imaging Signal transduction Dynamics Transforming growth factor beta receptor Epidermal growth factor receptor Total internal reflection fluorescence microscopy |
| 英文摘要 | Single-molecule fluorescence imaging with living cells offers a new approach to visualize and monitor individual proteins during their cellular activities. It facilities the study of cell signaling proteins whose structures and interactions are highly temporal and spatial regulated. In this review, we will mainly present our recent work on probing the dynamics of two types of important transmembrane growth factor receptors, transforming growth factor beta receptors and epidermal growth factor receptors, by single-molecule fluorescence microscopy. This includes the characterization of receptor stoichiometry, monomer-dimer interconversion kinetics, effects of microenvironment on receptor membrane diffusion, and intracellular transportation under different signaling conditions. Related studies on these receptors from other groups, as well as the method developments, will be also discussed. Single-molecule study helps to achieve a better understanding of the molecular mechanism of receptor activation, endocytosis and other molecular events in transmembrane signaling. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28423]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yahong,Li, Nan,Fang, Xiaohong. Probing the dynamics of growth factor receptor by single-molecule fluorescence imaging[J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY,2015,118(3):95-102. |
| APA | Sun, Yahong,Li, Nan,&Fang, Xiaohong.(2015).Probing the dynamics of growth factor receptor by single-molecule fluorescence imaging.PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY,118(3),95-102. |
| MLA | Sun, Yahong,et al."Probing the dynamics of growth factor receptor by single-molecule fluorescence imaging".PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 118.3(2015):95-102. |
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来源：化学研究所
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