Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins
文献类型：期刊论文
| 作者 | Zhang, Jianwei1,2; Chen, Fei1,2; He, Yan-Mei1,2; Fan, Qing-Hua1,2 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2015-04-07 |
| 卷号 | 54期号:15页码:4622-4625 |
| 关键词 | asymmetric catalysis enantioselectivity heterocycles hydrogenation ruthenium |
| 英文摘要 | The first asymmetric hydrogenation (AH) of 2,6-disubstituted and 2,3,6-trisubstituted 1,5-naphthyridines, catalyzed by chiral cationic ruthenium diamine complexes, has been developed. A wide range of 1,5-naphthyridine derivatives were efficiently hydrogenated to give 1,2,3,4-tetrahydro-1,5-naphthyridines with up to 99%ee and full conversions. This facile and green protocol is applicable to the scaled-up synthesis of optically pure 1,5-diaza-cis-decalins, which have been used as rigid chelating diamine ligands for asymmetric synthesis. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28553]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jianwei,Chen, Fei,He, Yan-Mei,et al. Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(15):4622-4625. |
| APA | Zhang, Jianwei,Chen, Fei,He, Yan-Mei,&Fan, Qing-Hua.(2015).Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(15),4622-4625. |
| MLA | Zhang, Jianwei,et al."Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.15(2015):4622-4625. |
入库方式： OAI收割
来源：化学研究所
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