Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs
文献类型：期刊论文
| 作者 | Wang, Chenhong1,2; Zhang, Kuo3; Wang, Heran1,2; Xu, Shanshan1; Han, Charles C.1 |
| 刊名 | POLYMER
 |
| 出版日期 | 2015-03-20 |
| 卷号 | 61页码:174-182 |
| 关键词 | Degradation PLGA scaffolds Implantation |
| 英文摘要 | Study of the degradation behavior of implants is of crucial importance in biomedical fields before practical applications. In this study, degradability of poly (DL-lactic-co-glycolic acid) (PDLGA)/poly (DL-lactide)-block-poly (ethylene glycol) (PDLA-b-PEG) scaffolds was evaluated both in vitro and in vivo. In vitro degradation of fibrous scaffolds showed that highly porous structure facilitated the diffusion of soluble degraded products out of the scaffolds. The electrospun scaffolds could maintain the structural integrity and the fibrous morphology in vitro for 8 weeks and during the wound healing process in vivo. When implanted in vivo, the scaffolds had good biocompatibility and degraded faster than in vitro. Long term study of degradation in rats showed that the scaffolds were totally degraded and absorbed. Faster degradation in pigs than in rats might due to the surgical condition and difference of physiological environment between rats and pigs, such as wound area, hemorrhage, the local motion and inflammatory reaction. The interaction between the scaffolds and the surrounding tissues would also influence the degradation of the implants. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28526]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Joint Lab Polymer Sci & Mat, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chenhong,Zhang, Kuo,Wang, Heran,et al. Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs[J]. POLYMER,2015,61:174-182. |
| APA | Wang, Chenhong,Zhang, Kuo,Wang, Heran,Xu, Shanshan,&Han, Charles C..(2015).Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs.POLYMER,61,174-182. |
| MLA | Wang, Chenhong,et al."Evaluation of biodegradability of poly (DL-lactic-co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs".POLYMER 61(2015):174-182. |
入库方式： OAI收割
来源：化学研究所
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