Isoniazid conjugated poly(lactide-co-glycolide): Long-term controlled drug release and tissue regeneration for bone tuberculosis therapy
文献类型：期刊论文
| 作者 | Huang, Da1; Li, Dawei2,3; Wang, Tiantian2; Shen, Hong1; Zhao, Pei1; Liu, Baoxia1; You, Yezi4; Ma, Yuanzheng2,3; Yang, Fei1; Wu, Decheng1 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 52页码:417-425 |
| 关键词 | Bone tuberculosis Drug delivery Bone repair Scaffolds Isoniazid |
| 英文摘要 | Bone tuberculosis (TB) is one of the most common extrapulmonary TB. Effective integration of chemotherapy and bone regeneration is an optimal solution for bone TB therapy. Herein, we produce a composite scaffold drug delivery system fabricated with an isoniazid conjugated star poly(lactide-coglycolide) (PLGA-INH4) and beta-TCP. The cytological assay indicated the composite system possesses good biocompatibility. The in vitro and in vivo drug release evaluations showed that the composite system can intactly release the pristine INH and maintain effective INH concentration in a controlled manner for more than 100 days, and achieve high localized drug concentration and low systemic drug concentration. The rabbit radius repair experiment testified the scaffold has good bone regeneration capacity. Our work demonstrate the composite system can simultaneously achieve localized long-term drug controlled release and bone regeneration, which provides a promising route for improved bone TB treatment. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28605]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China 2.309th Hosp PLA, Dept Orthopaed, Beijing 100094, Peoples R China 3.Southern Med Univ, Grad Sch, Guangzhou 510515, Guangdong, Peoples R China 4.Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Da,Li, Dawei,Wang, Tiantian,et al. Isoniazid conjugated poly(lactide-co-glycolide): Long-term controlled drug release and tissue regeneration for bone tuberculosis therapy[J]. BIOMATERIALS,2015,52:417-425. |
| APA | Huang, Da.,Li, Dawei.,Wang, Tiantian.,Shen, Hong.,Zhao, Pei.,...&Wang, Shenguo.(2015).Isoniazid conjugated poly(lactide-co-glycolide): Long-term controlled drug release and tissue regeneration for bone tuberculosis therapy.BIOMATERIALS,52,417-425. |
| MLA | Huang, Da,et al."Isoniazid conjugated poly(lactide-co-glycolide): Long-term controlled drug release and tissue regeneration for bone tuberculosis therapy".BIOMATERIALS 52(2015):417-425. |
入库方式： OAI收割
来源：化学研究所
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