Development of phenylboronic acid-functionalized nanoparticles for emodin delivery
文献类型：期刊论文
| 作者 | Wang, Bo1,2; Chen, Limin2; Sun, Yingjuan2; Zhu, Youliang2; Sun, Zhaoyan2; An, Tiezhu1; Li, Yuhua1; Lin, Yuan2; Fan, Daping3; Wang, Qian4 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:18页码:3840-3847 |
| 英文摘要 | Stable and monodisperse phenylboronic acid-functionalized nanoparticles (PBA-NPs) were fabricated using the 3-((acrylamido)methyl)phenylboronic acid homopolymer (PBAH) via the solvent displacement technique. The effect of operating parameters, including stirring time, initial polymer concentration and the proportion of methanol, on the self-assembly process was systematically investigated. The diameters of PBA-NPs were increased by increasing the initial PBAH concentration and the proportion of methanol. Likewise, there was a linear dependence between the size of self-assembled nanoparticles and the polymer concentration. Moreover, the dissipative particle dynamics (DPD) simulation technique was used to investigate the mechanism of self-assembly behavior of the PBAH, which indicated that the interior of PBA-NPs was hydrophobic and compact, and boronic acid groups were displayed on both the exterior and interior of PBA-NPs. The resulting PBA-NPs could successfully encapsulate emodin through PBA-diol interaction and the encapsulation efficiency (EE%) and drug loading content (DLC%) of drug-loaded PBA-NPs were 78% and 2.1%, respectively. Owing to the acid-labile feature of the boronate linkage, a reduction in environmental pH from 7.4 to 5.0 could trigger the disassociation of the boronate ester bonds, which could accelerate the drug release from PBA-emodin-NPs. Besides, PBA-emodin-NPs showed a much higher cytotoxicity to HepG2 cells (cancer cells) than MC-3T3-E1 cells (normal cells). These results imply that PBA-NPs would be a promising scaffold for the delivery of polyphenolic drugs. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28644]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Northeast Forestry Univ, Coll Life Sci, Harbin 150040, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Univ S Carolina, Sch Med, Columbia, SC 29208 USA 4.Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA |
| 推荐引用方式 GB/T 7714 | Wang, Bo,Chen, Limin,Sun, Yingjuan,et al. Development of phenylboronic acid-functionalized nanoparticles for emodin delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(18):3840-3847. |
| APA | Wang, Bo.,Chen, Limin.,Sun, Yingjuan.,Zhu, Youliang.,Sun, Zhaoyan.,...&Wang, Qian.(2015).Development of phenylboronic acid-functionalized nanoparticles for emodin delivery.JOURNAL OF MATERIALS CHEMISTRY B,3(18),3840-3847. |
| MLA | Wang, Bo,et al."Development of phenylboronic acid-functionalized nanoparticles for emodin delivery".JOURNAL OF MATERIALS CHEMISTRY B 3.18(2015):3840-3847. |
入库方式： OAI收割
来源：化学研究所
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