Biodegradable microspheres with poly(N-isopropylacrylamide) Enriched surface: Thermo-responsibility, biodegradation and drug release
文献类型：期刊论文
| 作者 | Yuan, Yin1; Sun, Pei-jian1; Shi, Xu-dong1; Gan, Zhi-hua1,2; Wang, Fo-song1 |
| 刊名 | CHINESE JOURNAL OF POLYMER SCIENCE
 |
| 出版日期 | 2015-11-01 |
| 卷号 | 33期号:11页码:1598-1605 |
| 关键词 | Microspheres Poly(N-isopropylacrylamide) Thermo-sensitive Biodegradation |
| 英文摘要 | Microspheres with thermo-responsible surface were fabricated by PCL-b-PEO-b-PNIPAM triblock copolymers. Thermo-responsible morphological changes of PCL-b-PEO-b-PNIPAM microspheres immersed in aqueous solution at temperatures above the LCST (e.g. 37 A degrees C) were observed from porous surface structure to compact surface layer. Enzymatic degradation and in vitro drug release results showed that the thermo-responsible surface layer greatly influenced the degradation of microspheres as well as the drug release behavior from microspheres. With the copolymerization of PNIPAM block into PCL-b-PEO copolymers, the drug release could be well regulated by changing temperatures and microspheres composition, which revealed the great potentials of microspheres with thermo-responsible surface for controlled drug release. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28412]  |
| 专题 | 化学研究所_工程塑料实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Coll Life Sci & Technol, Beijing Lab Biomed Mat, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yin,Sun, Pei-jian,Shi, Xu-dong,et al. Biodegradable microspheres with poly(N-isopropylacrylamide) Enriched surface: Thermo-responsibility, biodegradation and drug release[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2015,33(11):1598-1605. |
| APA | Yuan, Yin,Sun, Pei-jian,Shi, Xu-dong,Gan, Zhi-hua,&Wang, Fo-song.(2015).Biodegradable microspheres with poly(N-isopropylacrylamide) Enriched surface: Thermo-responsibility, biodegradation and drug release.CHINESE JOURNAL OF POLYMER SCIENCE,33(11),1598-1605. |
| MLA | Yuan, Yin,et al."Biodegradable microspheres with poly(N-isopropylacrylamide) Enriched surface: Thermo-responsibility, biodegradation and drug release".CHINESE JOURNAL OF POLYMER SCIENCE 33.11(2015):1598-1605. |
入库方式： OAI收割
来源：化学研究所
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