Dual-stimuli sensitive keratin graft PHPMA as physiological trigger responsive drug carriers
文献类型：期刊论文
| 作者 | Li, Qinmei1,2; Yang, Saina1,3; Zhu, Lijun1; Kang, Hongliang1; Qu, Xiaozhong3; Liu, Ruigang1; Huang, Yong1,4 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:15页码:2869-2878 |
| 英文摘要 | Keratin graft poly(N-(2-hydroxypropyl)methacrylamide) (K-g-PHPMA) copolymers were synthesized and characterized. On account of the thiol groups of keratin and the amphiphilicity of the graft copolymers, micelles with cleavable cross-links on a keratin core were fabricated in water. The K-g-PHPMA micelles can efficiently encapsulate doxorubicin (DOX) and can be used as a drug carrier. The DOX content in the micelles increases with the keratin content of the graft copolymers. The release of the encapsulated DOX in the micelles is sensitive to the physiological environment. Redox trigger glutathione (GSH), especially at the intracellular level, and trypsin can effectively trigger the release of the encapsulated DOX. In vitro cellular uptake experiments indicate that the DOX released from the DOX-loaded K-g-PHPMA micelles can be efficiently internalized into cells. Under higher GSH condition, the DOX shows a much faster release into the nucleus of the cells. The K-g-PHPMA copolymers have promising applications as drug carriers for enhanced intracellular drug delivery in cancer therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/28527]  |
| 专题 | 化学研究所_工程塑料实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Sate Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Beijing Ctr Phys & Chem Anal, Beijing Key Lab Organ Mat Testing Technol & Qual, Beijing 100089, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Tech Inst Phys & Chem, Nat Res Ctr Engn Plast, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qinmei,Yang, Saina,Zhu, Lijun,et al. Dual-stimuli sensitive keratin graft PHPMA as physiological trigger responsive drug carriers[J]. POLYMER CHEMISTRY,2015,6(15):2869-2878. |
| APA | Li, Qinmei.,Yang, Saina.,Zhu, Lijun.,Kang, Hongliang.,Qu, Xiaozhong.,...&Huang, Yong.(2015).Dual-stimuli sensitive keratin graft PHPMA as physiological trigger responsive drug carriers.POLYMER CHEMISTRY,6(15),2869-2878. |
| MLA | Li, Qinmei,et al."Dual-stimuli sensitive keratin graft PHPMA as physiological trigger responsive drug carriers".POLYMER CHEMISTRY 6.15(2015):2869-2878. |
入库方式： OAI收割
来源：化学研究所
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