An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging
文献类型：期刊论文
| 作者 | Jin, Xiaoying1,2; Fang, Fang3; Liu, Jianhua4; Jiang, Chunhuan5; Han, Xueli4; Song, Zhongkai1; Chen, Jinxing1; Sun, Guoying1,2; Lei, Hao3; Lu, Lehui5 |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:38页码:15680-15688 |
| 英文摘要 | Lanthanide-based multimodal probes with high sensitivity, simple synthesis strategy, and good bio-compatibility promise new applications for clinical diagnosis. However, today's challenge is not only to develop high-performance multimodal probes for more accurate and reliable diagnosis, but also to understand the fate of these probes in vivo. In this context, a novel PEGylated Dy-doped NaGdF4 nanoprobe (PEG-NaGdF4:Dy) was designed and fabricated as a T-1/T-2-weighted MRI/CT imaging agent. This nanoprobe has a distinct longitudinal relaxivity (r(1) = 5.17 mM(-1) s(-1)), relatively high transverse relaxivity (r(2) = 10.64 mM(-1) s(-1)), and exhibits strong X-ray attenuation properties (44.70 HU L g(-1)) in vitro. Furthermore, T-1/T-2-weighted MRI/CT imaging in vivo confirmed that this PEG-NaGdF4:Dy nanoprobe could lead to a significant contrast enhancement effect on liver, spleen and kidney at 24 h post injection. The MTT assay, histological analysis, and biodistribution investigation demonstrated that this multifunctional nanoprobe possessed relatively low cytotoxicity, negligible tissue damage and could be completely excreted out of the body of mice as time prolonged. Therefore, the present PEG-NaGdF4:Dy nanoprobe has the potential for the development of multifunctional T-1/T-2-weighted MRI/CT imaging to provide more comprehensive and accurate diagnosis information. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | RAY COMPUTED-TOMOGRAPHY ; UP-CONVERSION NANOPARTICLES ; IN-VIVO ; CONTRAST AGENTS ; MAGNETIC-RESONANCE ; MOLECULAR PROBES ; NANOCRYSTALS ; COMPLEXES ; THERAPY ; SIZE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361834100017 |
| 公开日期 | 2015-11-03 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8175]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Changchun Univ Technol, Sch Chem & Life Sci, Jilin Prov Key Lab Carbon Fiber Dev & Applicat, Changchun, Peoples R China 2.Changchun Univ Technol, Adv Inst Mat Sci, Changchun, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 4.Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Jilin, Peoples R China 5.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Xiaoying,Fang, Fang,Liu, Jianhua,et al. An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging[J]. NANOSCALE,2015,7(38):15680-15688. |
| APA | Jin, Xiaoying.,Fang, Fang.,Liu, Jianhua.,Jiang, Chunhuan.,Han, Xueli.,...&Lu, Lehui.(2015).An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging.NANOSCALE,7(38),15680-15688. |
| MLA | Jin, Xiaoying,et al."An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging".NANOSCALE 7.38(2015):15680-15688. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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