Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms
文献类型：期刊论文
| 作者 | Sun, Hong-Zhi1,5,6; Fang, Zhong-Ze2,3,4,5,6; Cao, Yun-Feng2,5,6; Sun, Xiao-Yu2,5,6; Hong, Mo2,5,6 |
| 刊名 | phytotherapy research
 |
| 出版日期 | 2013-05-01 |
| 卷号 | 27期号:5页码:705-712 |
| 关键词 | evodiamine cytochrome P450 (CYP) human liver microsomes (HLMs) |
| 英文摘要 | evodiamine is the main active alkaloid of evodia rutaecarpa (e. rutaecarpa) and has been demonstrated to exhibit many pharmacological activities including vasorelaxation, uterotonic action, anoxia and control of body temperature. the present study focused on the metabolism of evodiamine. human and phenobarbital-induced rat liver microsomal incubation of evodiamine in the presence of nadph resulted in the formation of five major metabolites (m-1, m-2, m-3, m-4, m-5). four metabolites (m-1, m-2, m-3 and m-5) were identified to mono-hydroxylated evodiamine and one metabolite (m-4) was identified to be n-demethylated evodiamine. cyp3a4, cyp2c9 and cyp1a2 were identified to be the main cyp isoforms involved in the metabolism of evodiamine in human liver microsomes. finding new metabolites can help us decipher novel substance basis of efficiency and toxicity. elucidation of drug metabolizing enzymes will facilitate explaining the individual difference for response to the same drugs or herbs and the potential drugdrug interaction or herbdrug interaction. taken together, these results are of significance for better understanding the pharmacokinetic behaviour of evodiamine and helpful for clinical application of evodiamine and e. rutaecarpa. copyright (c) 2012 john wiley & sons, ltd. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | pharmacological-properties ; galenical preparation ; liver microsomes ; identification ; rutaecarpine ; rats ; pharmacokinetics ; alkaloids ; apoptosis ; cells |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318031500011 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137496]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Liaoning Med Univ, Affiliated Hosp 1, Jinzhou 121001, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 3.Liaoning Med Univ, Jinzhou 121001, Peoples R China 4.NCI, Lab Metab, Ctr Canc Res, Bethesda, MD 20892 USA 5.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian 116023, Peoples R China 6.Liaoning Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Hong-Zhi,Fang, Zhong-Ze,Cao, Yun-Feng,et al. Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms[J]. phytotherapy research,2013,27(5):705-712. |
| APA | Sun, Hong-Zhi,Fang, Zhong-Ze,Cao, Yun-Feng,Sun, Xiao-Yu,&Hong, Mo.(2013).Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms.phytotherapy research,27(5),705-712. |
| MLA | Sun, Hong-Zhi,et al."Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms".phytotherapy research 27.5(2013):705-712. |
入库方式： OAI收割
来源：大连化学物理研究所
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