Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS
文献类型：期刊论文
| 作者 | Chen, Shili1; Yin, Peiyuan1; Zhao, Xinjie1; Xing, Wenbin2; Hu, Chunxiu1; Zhou, Lina1; Xu, Guowang1 |
| 刊名 | electrophoresis
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 34期号:19页码:2848-2856 |
| 关键词 | Lipidomics LC-MS Liver disease Metabolomics Phospholipids |
| 英文摘要 | in this study, an ultra fast lc/it-tof ms (uflc/it-tof ms)-based serum lipidomics method was employed to characterize the serum lipid profile of patients with chronic hepatitis b, cirrhosis, and hepatocellular carcinoma (hcc). after data collection and processing, 96 lipids including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins, triacylglycerides, and cholesterol esters were identified and used for subsequent data analysis. partial least squares-discriminant analysis revealed that patients with liver diseases had distinctly different serum lipid profile from that of healthy controls; while cirrhosis and hcc patients had a similar serum lipid profile, but different from that of hepatitis patients. the anova analysis found 75 of the 96 identified lipids to be abnormally regulated, among which most of these lipids were downregulated in cirrhosis and hcc patients compared with those of healthy controls and hepatitis patients, while hepatitis patients induced several lipids downregulated and others upregulated compared with those of healthy controls, indicating the aberrant lipid metabolism in patients with liver diseases. this work demonstrated the utility of uflc/it-tof ms-based serum lipidomics as a powerful tool to investigate the lipid metabolism of liver diseases. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | phosphatidylethanolamine n-methyltransferase ; nonalcoholic fatty liver ; acute viral-hepatitis ; lysophosphatidic acid ; mass spectrometry ; c virus ; in-situ ; cancer ; metabolism ; expression |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327667800009 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137498]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Sixth Peoples Hosp Dalian, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shili,Yin, Peiyuan,Zhao, Xinjie,et al. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS[J]. electrophoresis,2013,34(19):2848-2856. |
| APA | Chen, Shili.,Yin, Peiyuan.,Zhao, Xinjie.,Xing, Wenbin.,Hu, Chunxiu.,...&Xu, Guowang.(2013).Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS.electrophoresis,34(19),2848-2856. |
| MLA | Chen, Shili,et al."Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT-TOF MS".electrophoresis 34.19(2013):2848-2856. |
入库方式： OAI收割
来源：大连化学物理研究所
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