Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication
文献类型：期刊论文
| 作者 | Wang, Xia1; Xu, Xue1; Li, Yan2; Li, Xiuxiu1; Tao, Weiyang1; Li, Bohui1; Wang, Yonghua1,3; Yang, Ling4 |
| 刊名 | integrative biology
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:2页码:351-371 |
| 英文摘要 | given the imminent threat of influenza pandemics and continuing emergence of new drug-resistant influenza virus strains, novel strategies for preventing and treating influenza disease are urgently needed. herbal medicine, used for thousands of years in combinational therapies (herb formula), plays a significant role in stimulating the host immune system in vivo, and meanwhile, in fighting against the pandemic by directly inhibiting influenza virus in vitro. such potential janus functions may spark interest in therapeutic manipulation of virus diseases. unfortunately, the molecular mechanism of the janus functions of the medicinal herbs in the treatment of influenza remains unclear. in this work, to illustrate the therapeutic concept of janus functions in the treatment of influenza, we have introduced a novel systems pharmacology model that integrates pharmacokinetic screening, targeting and network analysis of two representative herbs lonicera japonica and fructus forsythiae that are efficient in the treatment of influenza, inflammation and other diseases. 50 chemicals with favorable pharmacokinetic profiles have been identified for the two herbs, and the ligand-target network was constructed by complementing the literature-based experimental data deposited in drugbank. the annotation of these chemicals was assigned using a novel drug targeting approach, and mapped to target-disease and drug-target-pathway networks. the overall data suggest that the medicinal herbs function by indirectly suppressing the virus proliferation via regulating the immune systems in hosts, and also, by directly inhibiting virus proliferation through targeting viral proteins essential for the viral life cycle. for the first time, we have demonstrated the mechanism of medicinal herbs in prevention and treatment of virus diseases via the janus functions on a systematic level. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | cell biology |
| 研究领域[WOS] | cell biology |
| 关键词[WOS] | traditional chinese medicine ; nf-kappa-b ; therapeutic target database ; lonicera-japonica thunb. ; pregnane-x receptor ; st-johns-wort ; antiinflammatory activity ; forsythia-suspensa ; neuraminidase inhibitors ; antibacterial activity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314265900008 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137528]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.NW A&F Univ, Coll Life Sci, Yangling 712100, Shaanxi, Peoples R China 2.Dalian Univ Technol, Sch Chem Engn, Dalian 116012, Liaoning, Peoples R China 3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xia,Xu, Xue,Li, Yan,et al. Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication[J]. integrative biology,2013,5(2):351-371. |
| APA | Wang, Xia.,Xu, Xue.,Li, Yan.,Li, Xiuxiu.,Tao, Weiyang.,...&Yang, Ling.(2013).Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication.integrative biology,5(2),351-371. |
| MLA | Wang, Xia,et al."Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication".integrative biology 5.2(2013):351-371. |
入库方式： OAI收割
来源：大连化学物理研究所
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