Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry
文献类型：期刊论文
| 作者 | Sui, Zhigang1,2; Li, Na2; Liu, Zhiqiang3; Yan, Jun1; Liu, Zhongying1 |
| 刊名 | xenobiotica
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 43期号:7页码:628-635 |
| 关键词 | Aconitine fragmentation pathway LC/ESI/MSn metabolites stomach |
| 英文摘要 | 1. aconitine (ac), an active and highly toxic constituent extracted from aconitum plants, is well known for its excellent effects against rheumatism and rheumatoid arthritis. the metabolism of ac in liver and intestine has been previously reported. however, little is known about the metabolism of ac in stomach. in this study, the metabolite profiling of ac in stomachs of rabbit and rat was performed by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry (lc/esi/msn), for the first time. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | pharmacology & pharmacy ; toxicology |
| 研究领域[WOS] | pharmacology & pharmacy ; toxicology |
| 关键词[WOS] | human intestinal bacteria ; tissue distribution ; main metabolite ; alkaloids ; rats ; biotransformation |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319881000007 |
| 公开日期 | 2015-11-10 |
| 源URL | [http://159.226.238.44/handle/321008/137560]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jilin Univ, Coll Pharm, Changchun 130021, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 3.Chinese Acad Sci, Chang Chun Inst Appl Chem, Changchun, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sui, Zhigang,Li, Na,Liu, Zhiqiang,et al. Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry[J]. xenobiotica,2013,43(7):628-635. |
| APA | Sui, Zhigang,Li, Na,Liu, Zhiqiang,Yan, Jun,&Liu, Zhongying.(2013).Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry.xenobiotica,43(7),628-635. |
| MLA | Sui, Zhigang,et al."Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple- stage tandem mass spectrometry".xenobiotica 43.7(2013):628-635. |
入库方式： OAI收割
来源：大连化学物理研究所
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